{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:24:18Z","timestamp":1790533458945,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Since the identification of the &lt;i&gt;FIP1L1\/PDGFRA&lt;\/i&gt; fusion gene as a pathogenic cause of the hypereosinophilic syndrome (HES), the importance of the molecular classification of HES leading to the diagnosis of chronic eosinophilic leukemia (CEL) has been recognized. As a result, a new category, \u2018myeloid and lymphoid neoplasm with eosinophilia and abnormalities in PDGFRA, PDGFRB or FGFR1\u2019, has recently been added to the new WHO criteria for myeloid neoplasms. FIP1L1\/PDGFR\u03b1-positive disorders are characterized by clonal hypereosinophilia, multiple organ dysfunctions due to eosinophil infiltration, systemic mastocytosis (SM) and a dramatic response to treatment with imatinib mesylate. A murine HES\/CEL model by the introduction of FIP1L1\/PDGFR\u03b1 and IL-5 overexpression also shows SM, representing patients with FIP1L1\/PDGFR\u03b1-positive HES\/CEL\/SM. The murine model and the in vitro development system of FIP1L1\/PDGFR\u03b1-positive mast cells revealed the interaction between FIP1L1\/PDGFR\u03b1, IL-5 and stem cell factor in the development of HES\/CEL\/SM. Current findings of FIP1L1\/PDGFR\u03b1-positive HES\/CEL are reviewed focusing on aberrant mast cell development leading to SM.<\/jats:p>","DOI":"10.1159\/000312134","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T07:34:13Z","timestamp":1275636853000},"page":"101-105","source":"Crossref","is-referenced-by-count":15,"title":["FIP1L1\/PDGFR\u03b1-Associated Systemic Mastocytosis"],"prefix":"10.1159","volume":"152","author":[{"given":"Yoshiyuki","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Cancelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa025217"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2007.06628.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404154"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fgcc.20359"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404955"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fleu.2008.287"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS1535-6108%2803%2900108-9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2005-08-3153"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2007-11-126268"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2007.05.024"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0145-2126%2803%2900065-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2891%2990214-I"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.24.021605.090720"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2009-07-143552"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-07-2479"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.leu.2404977"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20050548"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2332%2Fallergolint.08-RAI-0067"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.186.2.313"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2004.00606.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-05-1627"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2005.05863.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000092708"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/312134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/312134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:25:39Z","timestamp":1745436339000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000312134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":23,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000312134","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}