{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:50:25Z","timestamp":1790250625001,"version":"4.1.0"},"reference-count":29,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although characteristics of intraepithelial lymphocytes (IELs) in mucosal immunity have been well defined in the intestine, bronchial IELs have been little investigated. Recently, we showed that bronchial IELs have a distinct function that partly resembles that of intestinal IELs; however, surface antigen expression of bronchial IELs and the relationship of that expression to airway disease have not been studied. &lt;i&gt;Methods:&lt;\/i&gt; We analyzed phenotypic profiles of human bronchial IELs and lamina propria lymphocytes (LPLs) by double-staining immunohistochemistry using full-thickness bronchial specimens (10 nonasthmatic controls and 7 asthmatics) from lung resections. &lt;i&gt;Results:&lt;\/i&gt; In controls, the percentage of CD4+ cells was lower, and the percentage of CD8+ cells was higher in IELs compared to LPLs (CD4: median 50.0% in IELs vs. 65.9% in LPLs, p = 0.01; CD8: 50.9% in IELs vs. 34.4% in LPLs, p = 0.007). The percentage of cells positive for CD103 (\u03b1E-integrin) was higher in IELs than that in LPLs (median 60.1% in IELs vs. 16.9% in LPLs; p &lt; 0.001). In IELs from asthmatics, these characteristics were particularly significant (CD4: median 26.2%, p = 0.008; CD8: 79.8%, p = 0.007; CD103: 76.2%, p = 0.019; all compared with IELs from nonasthmatics). &lt;i&gt;Conclusions:&lt;\/i&gt; These results suggest that human bronchial IELs have roles distinct from subsets of other lymphocytes, and that CD8+ cells and CD103+ cells have potentially important functions in the bronchial epithelium.<\/jats:p>","DOI":"10.1159\/000312633","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T06:56:19Z","timestamp":1272264979000},"page":"157-165","source":"Crossref","is-referenced-by-count":12,"title":["CD8 and CD103 Are Highly Expressed in Asthmatic Bronchial Intraepithelial Lymphocytes"],"prefix":"10.1159","volume":"153","author":[{"given":"Susumu","family":"Hirosako","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Goto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Tsumori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotsugu","family":"Kohrogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.176.1.187"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7973709"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.25.2.158"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2005.02.003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200310-1416OC"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2006.03167.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2001.01099.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.110100"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2249.2008.03811.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2F1521-4141%28200003%2930%3A3%3C819%3A%3AAID-IMMU819%3E3.0.CO%3B2-Y"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-1759%2899%2900243-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.27.8.972"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830200523"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830230231"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830170910"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1006%2Fcimm.1996.0013"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2800%2990066-6"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200504-619OC"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.169"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.94.07030437"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2003.01686.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.06.00032906"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2008.09.014"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2F372190a0"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002%2Feji.1830211041"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1006%2Fexmp.2001.2376"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2889%2990067-6"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1136%2Fthorax.56.6.450"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2F0952-7915%2893%2990012-H"}],"container-title":["International 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