{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:34:44Z","timestamp":1773290084035,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Insect venom allergy (IVA) is present in 1\u20133% of the population. A group of patients with high specific IgE do not react to stings. In contrast, a proportion of patients with IVA have low specific IgE levels. These findings indicate that factors other than specific IgE may also be involved in IVA. Dysfunction of the renin-angiotensin system (RAS) has been described as a potential factor in IVA. The objective of this study was to determine the prevalence of angiotensin <i>AGT<\/i> p.M235T and angiotensin-converting enzyme <i>ACE<\/i> I\/D, I\/I, D\/D gene polymorphisms in patients with IVA and to relate the presence of these gene variants to the course of IVA and the safety of treatment. <i>Methods:<\/i> A total of 107 patients with IVA and 113 controls were studied. <i>AGT<\/i> p.M235T and <i>ACE<\/i> (ID, I\/I, D\/D) gene polymorphisms were examined, and angiotensin I levels were measured by immunoassay. <i>Results:<\/i> The frequency of the <i>AGT<\/i> MM M235T variant was significantly higher in IVA patients (29.9%) than in controls (17%, p = 0.02). The presence of the MM M235T genotype increased the risk of grade IV reactions (odds ratio = 2.5 and 95% confidence interval 1.04\u20136.08). There were no differences in the prevalence of the <i>ACE<\/i> I\/D polymorphism and angiotensin I levels between control groups and patients with different grades of anaphylactic reactions or patients with side effects of venom immunotherapy. <i>Conclusion:<\/i> The <i>AGT<\/i> M235T MM variant may be responsible for severe anaphylactic reactions to insect venom allergens in some patients.<\/jats:p>","DOI":"10.1159\/000312634","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T06:56:19Z","timestamp":1272264979000},"page":"166-172","source":"Crossref","is-referenced-by-count":10,"title":["The Angiotensinogen <i>AGT<\/i> p.M235T Gene Polymorphism May Be Responsible for the Development of Severe Anaphylactic Reactions to Insect Venom Allergens"],"prefix":"10.1159","volume":"153","author":[{"given":"Marek","family":"Niedoszytko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Ratajska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Che\u0142mi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Makowiecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Malek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Siemi\u0144ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Limon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Jassem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2005.00963.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2005.00960.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2FACI.0b013e328306a007"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2FACI.0b013e3283036a69"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F02770906609106941"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000237462"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000236695"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000236621"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1993.tb00364.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000237045"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1139%2FH07-147"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114844"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.11.4331"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2897%2900402-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199503163321103"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2900902-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2981044-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2899%2970246-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00724.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2008.02965.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.1G295"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2960321-3"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mcna.2005.08.007"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2006.01175.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F00024382-200014050-00013"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2898%2970068-5"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2332%2Fallergolint.55.355"}],"container-title":["International 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