{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:56:34Z","timestamp":1791273394147,"version":"4.1.0"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> The aims of this study were to determine the most effective solvent extract of mangosteen, anti-acne- inducing bacterial activity and the amount of \u03b1-mangostin, a major active component in each mangosteen fruit rind extract, using high-performance liquid chromatography (HPLC). <i>Materials and Methods:<\/i> The fruit rinds of mangosteen were extracted with hexane, dichloromethane, ethanol and water. The extracts were tested for antibacterial activity against bacteria that induce acne, including <i>Propionibacterium acnes<\/i> and<i> Staphylococcus epidermidis<\/i>. Thin-layer chromatographic autobiography against these bacteria was also performed for each extract, while the \u03b1-mangostin content was analyzed using a validated HPLC method. <i>Results:<\/i> The dichloromethane extract exhibited the strongest antibacterial effect with minimum inhibitory concentration values for both bacterial species at 3.91 \u00b5g\/ml, while the minimum bactericidal concentration values against <i>P. acnes <\/i>and<i> S. epidermidis <\/i>were 3.91 and 15.63 \u00b5g\/ml, respectively. Thin-layer chromatographic autobiography indicated that \u03b1-mangostin was present in all extracts, except the water extract, and is a major active component against both <i>P. acnes <\/i>and<i> S. epidermidis<\/i>. Using HPLC, the dichloromethane extract yielded the highest content (46.21% w\/w) of \u03b1-mangostin followed by the ethanol extract (18.03% w\/w), the hexane extract (17.21% w\/w) and the water extract (0.54% w\/w). <i>Conclusions:<\/i> Dichloromethane extract exhibited the strongest anti-acne-inducing bacterial effect and this extract yielded the highest amount of \u03b1-mangostin.<\/jats:p>","DOI":"10.1159\/000312714","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T07:59:57Z","timestamp":1274947197000},"page":"281-286","source":"Crossref","is-referenced-by-count":39,"title":["Anti-Acne-Inducing Bacterial Activity of Mangosteen Fruit Rind Extracts"],"prefix":"10.1159","volume":"19","author":[{"given":"Werayut","family":"Pothitirat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mullika Traidej","family":"Chomnawang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wandee","family":"Gritsanapan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,5,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1586%2F17469872.3.1.111"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.2003.12321.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fct.2008.07.024"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000092991"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1179%2F147683009X388850"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.etp.2008.11.002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2006-957916"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2005.04.038"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fitote.2009.06.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0273-2300%2883%2990038-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0300-483X%2801%2900438-3"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/312714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/312714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:04:59Z","timestamp":1745435099000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000312714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000312714","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}