{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:04:28Z","timestamp":1788019468016,"version":"build-2784847793"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,4,23]],"date-time":"2010-04-23T00:00:00Z","timestamp":1271980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,4,23]],"date-time":"2010-04-23T00:00:00Z","timestamp":1271980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Cinacalcet, an allosteric modulator of the calcium-sensing receptor, effectively reduces serum parathyroid hormone (PTH). It was examined whether a regression of parathyroid glands in hemodialysis patients with secondary hyperparathyroidism was induced by cinacalcet treatment. &lt;i&gt;Methods:&lt;\/i&gt; Ultrasonography of the parathyroid glands was performed to examine the changes in the parathyroid gland volumes after cinacalcet treatment in 58 patients. &lt;i&gt;Results:&lt;\/i&gt; After cinacalcet treatment, serum calcium, phosphate, alkaline phosphatase, and intact PTH significantly decreased (p &lt; 0.0001). The total volumes of the parathyroid glands were significantly decreased 6 months after cinacalcet treatment (942 \u00b1 747 vs. 708 \u00b1 550 mm&lt;sup&gt;3&lt;\/sup&gt;, p &lt; 0.0005). There was a significant positive correlation between the parathyroid gland volumes at the start of cinacalcet treatment and the volume reduction in parathyroid glands (r = 0.716, p &lt; 0.0001). Of the 58 patients, the total parathyroid gland volume was decreased in 42 patients and increased in 16 although the doses of cinacalcet, phosphate binders or vitamin D were not significantly different. In both groups, the intact PTH serum levels were significantly decreased after cinacalcet treatment. &lt;i&gt;Conclusion:&lt;\/i&gt; Cinacalcet treatment in patients with secondary hyperparathyroidism significantly reduced the total parathyroid gland volume in a short 6-month period. This study suggests that cinacalcet treatment may postpone parathyroidectomy and\/or reduce cases.<\/jats:p>","DOI":"10.1159\/000313035","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T06:56:19Z","timestamp":1272264979000},"page":"c195-c202","source":"Crossref","is-referenced-by-count":22,"title":["Decreases in Parathyroid Gland Volume after Cinacalcet Treatment in Hemodialysis Patients with Secondary Hyperparathyroidism"],"prefix":"10.1159","volume":"115","author":[{"given":"Mitsuru","family":"Ichii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Ishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senji","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Tsuboniwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Nagasue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Maekawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Nishizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2007.00540.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118701"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ackd.2006.10.009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.103.057273"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031633"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004060512"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh966"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm534"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm177"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119851"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.67103.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00837.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2007.07.177"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn579"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn654"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2008.00648.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg451"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000156717"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:08:00Z","timestamp":1745435280000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000313035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,23]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000313035","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,23]]}}}