{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:16:46Z","timestamp":1760908606949,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate bone mineral density (BMD), fractures, and vitamin D deficiency in pediatric patients in complete remission of solid tumor; and to identify risk factors for these three abnormalities. &lt;i&gt;Study Design:&lt;\/i&gt; Data were collected prospectively after completion of cancer treatment. Hormonal and vitamin D deficiencies were treated. The patients were evaluated again 1 year later. &lt;i&gt;Patients:&lt;\/i&gt; 52 consecutive patients, 30 boys and 22 girls. Among them, 21 completed the second evaluation. &lt;i&gt;Measurements:&lt;\/i&gt; A clinical examination, nutritional assessment, and laboratory workup were performed. BMD was measured by absorptiometry. &lt;i&gt;Results:&lt;\/i&gt; Calcium intake was inadequate in 75% of patients and vitamin D reserves were low in 61.5%. BMD was low at the spine in 32.7%, and at the femur in 24% of patients. Spinal and femoral BMD Z-scores correlated significantly with each other. Femoral BMD Z-score showed significant positive correlations with changes in body mass index, urinary calcium\/creatinine ratio, and time since treatment completion, and a significant negative correlation with treatment duration. Fractures were noted in 10 patients but were not correlated with BMD. In the 21 re-evaluated patients, no significant improvements were found in calcium intake, vitamin D status, or BMD Z-score. &lt;i&gt;Conclusions:&lt;\/i&gt; Survivors of childhood solid cancer have high rates of insufficient calcium intake, vitamin D deficiency, low bone mass and fractures.<\/jats:p>","DOI":"10.1159\/000313378","type":"journal-article","created":{"date-parts":[[2010,11,2]],"date-time":"2010-11-02T07:59:37Z","timestamp":1288684777000},"page":"319-327","source":"Crossref","is-referenced-by-count":30,"title":["Low Bone Mineral Density and High Incidences of Fractures and Vitamin D Deficiency in 52 Pediatric Cancer 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