{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:37Z","timestamp":1745469397714,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"7-8","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Objective:<\/i> The aim of this study was to investigate experts\u2019 opinions regarding the extent to which the introduction of pretesting for polymorphism of serotonin transporter promoter region (5-HTTLPR) as a routine intervention in clinical practice would lead to better clinical outcomes for depression patients. <i>Methods:<\/i> Using an internet survey system, authors of clinical studies addressing the topic of association of 5-HTTLPR genotyping with antidepressant response were contacted to participate in a Delphi study. <i>Results:<\/i> Responses from 12 experts were used for the final analysis. According to the participants, the introduction of 5-HTTLPR genotyping will lead to 33.8, 48.2, 57.8, and 65.1% of patients reaching remission at 1, 2, 3, and 6 months, respectively. <i>Conclusions:<\/i> According to experts, application of 5-HTTLPR pretreatment genotyping might influence remission; however, the estimated remission rates with genotyping at first sight do not appear to be superior to existing practice, i.e. without genotyping. It is anticipated that a combination of 5-HTTLPR testing with other genomic variables, which have yet to be determined, and compliance measurements can improve clinical outcomes in the future. At present, the introduction of 5-HTTLPR genotyping is expected to be used only in special situations.<\/jats:p>","DOI":"10.1159\/000313467","type":"journal-article","created":{"date-parts":[[2010,7,6]],"date-time":"2010-07-06T07:00:59Z","timestamp":1278399659000},"page":"406-414","source":"Crossref","is-referenced-by-count":6,"title":["Anticipated Outcomes from Introduction of 5-HTTLPR Genotyping for Depressed Patients: An Expert Delphi Analysis"],"prefix":"10.1159","volume":"13","author":[{"given":"S.","family":"Oestergaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"M\u00f8ldrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,7,6]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1001%2Fjama.286.23.2947"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.4088%2FJCP.v67n1203"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1097%2F01213011-200502000-00001"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1080%2F09540260400014369"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1080%2F09540260701563460"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1046%2Fj.1471-4159.1996.66062621.x"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.2147%2Fnedt.1.1.17.52301"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016%2Fj.healthpol.2008.05.011"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016%2FS0040-1625%2899%2900061-X"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1111%2Fj.1524-4733.2007.00169.x"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.2217%2Fpme.09.32"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.2174%2F1570160043377358"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159%2F000078225"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1186%2F1745-0179-2-13"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.4088%2FJCP.v65n0906"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1097%2F01.yic.0000139342.22133.77"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1097%2F00004850-200405000-00005"},{"doi-asserted-by":"publisher","key":"ref18","DOI":"10.4088%2FJCP.v66n1015"},{"doi-asserted-by":"publisher","key":"ref19","DOI":"10.1016%2Fj.jpsychires.2008.09.008"},{"doi-asserted-by":"publisher","key":"ref20","DOI":"10.1002%2Fda.20458"},{"doi-asserted-by":"publisher","key":"ref21","DOI":"10.1192%2Fbjp.181.3.208"},{"doi-asserted-by":"publisher","key":"ref22","DOI":"10.1016%2Fj.pnpbp.2005.11.020"},{"doi-asserted-by":"publisher","key":"ref23","DOI":"10.1097%2F01.ypg.0000107928.32051.11"},{"doi-asserted-by":"publisher","key":"ref24","DOI":"10.1097%2F00008571-200409000-00005"},{"doi-asserted-by":"publisher","key":"ref25","DOI":"10.1016%2Fj.clinthera.2007.04.018"},{"doi-asserted-by":"publisher","key":"ref26","DOI":"10.1586%2F14737159.6.3.277"},{"doi-asserted-by":"publisher","key":"ref27","DOI":"10.2165%2F00023210-200923030-00001"},{"doi-asserted-by":"publisher","key":"ref28","DOI":"10.1016%2Fj.cll.2008.05.006"},{"doi-asserted-by":"publisher","key":"ref29","DOI":"10.1038%2Fclpt.2009.2"},{"doi-asserted-by":"publisher","key":"ref30","DOI":"10.1074%2Fjbc.M806907200"},{"doi-asserted-by":"publisher","key":"ref31","DOI":"10.1038%2Fnpp.2008.148"},{"doi-asserted-by":"publisher","key":"ref32","DOI":"10.1097%2FFPC.0b013e32831a6a3a"},{"doi-asserted-by":"publisher","key":"ref33","DOI":"10.1038%2Ftpj.2009.12"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313467","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:11:56Z","timestamp":1745435516000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000313467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":33,"journal-issue":{"issue":"7-8","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000313467","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"type":"print","value":"1662-4246"},{"type":"electronic","value":"1662-8063"}],"subject":[],"published":{"date-parts":[[2010]]}}}