{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:27:47Z","timestamp":1760783267652,"version":"3.40.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T00:00:00Z","timestamp":1272412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T00:00:00Z","timestamp":1272412800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background:<\/i> Muscle function is impaired in uraemic patients and several causes have been proposed. Deficiency of 25-hydroxyvitamin D (25-OHD), which affects muscle function in non-uraemic patients, may very well also be associated with the myopathy found in these patients. The aim of this study was to investigate the association between 25-OHD and muscle function as well as physical function in chronic kidney disease (CKD) and peritoneal dialysis (PD) patients. <i>Methods:<\/i> In this cross-sectional study, 21 adult patients with CKD stage 3\u20135 and 21 patients treated with PD were included. Standard biochemistry parameters were measured including 25-OHD, 1,25-dihydroxycholecalciferol (1,25-OHD) and parathyroid hormone analysis. Muscle function was determined by 30-second surface electromyography (sEMG) recordings of a right thigh muscle (vastus lateralis) and a second left finger muscle (second dorsal interosseous) under voluntary contractions. Physical function was determined using a 30-second Chair Stand Test and the Short Form 36 quality of life questionnaire. Clinical characteristics were collected from the patient records. <i>Results:<\/i> Moderate vitamin 25-OHD deficiency (<40 nmol\/l) was measured in 52% of patients with CKD and in 71% of the patients on PD. Severe deficiency (<15 nmol\/l) was measured in 14% of patients on PD. There were no significant differences between the CKD and PD patients in terms of sEMG results. 25-OHD was not correlated to any results from the tests of sEMG or physical function. However, a higher sEMG frequency and signal root mean square (RMS) were positively associated with a higher Chair Stand Test score. Time to maximum sEMG frequency was negatively correlated to the Chair Stand Test score (p < 0.05), and positively correlated to the level of comorbidity (p < 0.05). sEMG signal peak-peak amplitude, frequency and RMS were positively correlated to the quality of life scales Physical Function, Role Physical, General Health, Vitality, Social Function, Mental Health, and Physical Component Scale (p < 0.001). <i>Conclusions:<\/i> 25-OHD deficiency was prevalent in uraemic patients in the present study. Muscle function as determined using sEMG and the Chair Stand Test was not associated with 25-OHD. The results may be biased by the limited variation in 25-OHD and masked by effects of several other variables in this very sick population.<\/jats:p>","DOI":"10.1159\/000313482","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T06:58:23Z","timestamp":1272437903000},"page":"c244-c250","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D, Surface Electromyography and Physical Function in Uraemic Patients"],"prefix":"10.1159","volume":"115","author":[{"given":"J.G.","family":"Heaf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Molsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Eiken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Prescott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Eidemak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,4,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exger.2006.05.001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000087203"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2F.424"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.2003.18.2.343"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinternmed.2007.31"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00614.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F12.1.119"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109%2F00365599609182300"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000090221"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.00954.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006060573"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000108652"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.jrn.2008.05.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.06-6374fje"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra070553"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-72-1-157"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000098561"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.04.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002451"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.501"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.07s212"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313482","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:12:01Z","timestamp":1745435521000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000313482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,28]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000313482","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2010,4,28]]}}}