{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:48:03Z","timestamp":1790837283390,"version":"4.1.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>The methionine (MET) dependency of tumor cells opens interesting perspectives for targeting tumor cells and potentiating chemotherapy treatment, like 5-fluorouracil (5-FU) and platinum compound. Since MET deprivation can individually potentiate the different chemotherapeutic agents used in the 48-hour combined regimen of 5-FU, leucovorin and oxaliplatin (FOLFOX) regimen, we initiated a feasibility study associating dietary MET restriction with the FOLFOX regimen in patients with metastatic colorectal cancer. &lt;i&gt;Objectives:&lt;\/i&gt; (i) To evaluate the depletion in the plasma MET concentration, and (ii) to assess the feasibility of this combination. &lt;i&gt;Methods:&lt;\/i&gt; Eleven patients were enrolled in this study. They received a median number of 3 two-week cycles of a MET-free diet (3 consecutive days) and FOLFOX6 regimen. &lt;i&gt;Results:&lt;\/i&gt; The plasma MET concentration was reduced by dietary MET restriction, with a depletion of 58% on the 1st day of MET-free diet. Indeed, we demonstrated the feasibility and good tolerance (nutritional status and toxicity) of the association of a MET-free diet with the FOLFOX regimen. Despite good compliance to the diet, this study revealed the difficulty of administering this combination during further months. Among the 4 patients evaluable for response, 3 experienced a partial response and 1 patient a disease stabilization.<\/jats:p>","DOI":"10.1159\/000313700","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T06:56:19Z","timestamp":1272264979000},"page":"205-209","source":"Crossref","is-referenced-by-count":56,"title":["Dietary Methionine Restriction with FOLFOX Regimen as First Line Therapy of Metastatic Colorectal Cancer: A Feasibility Study"],"prefix":"10.1159","volume":"78","author":[{"given":"Xavier","family":"Durando","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Chantal","family":"Farges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Buc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Abrial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Petorin-Lesens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Gillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Paule","family":"Vasson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Pezet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Thivat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.71.4.1133"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F82.20.1628"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0305-7372%2803%2900118-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0024-3205%2896%2900672-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.161.227"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-2952%2801%2900560-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.10-90003-40"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1081%2FCNV-120030208"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fjnci%2F92.3.205"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1207%2FS15327914NC422_2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-03-0068"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-04-1406"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-04-1822"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.05.113"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10620-006-9298-7"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313700","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/313700","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:14:34Z","timestamp":1745435674000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000313700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":15,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000313700","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}