{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:54:43Z","timestamp":1773280483286,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> Various methods have been described for safely performing fiberoptic bronchoscopy (FB) while applying non-invasive positive pressure ventilation (NIPPV) in patients with acute respiratory failure (ARF). <i>Objectives:<\/i> To evaluate the safety of a new method to perform FB in patients with ARF. <i>Methods:<\/i> Patients with ARF in whom FB was indicated were studied. The primary end-point was a mean drop in oxygen saturation (S<sub>a<\/sub><i>O<\/i><sub>2<\/sub>) after the procedure. During nasal NIPPV, FB was performed via the mouth using a bite block sealed with an elastic glove finger allowing bronchoscope insertion. <i>Results:<\/i> Thirty-five patients were included in the final study (63 \u00b1 17 years, 74% men, P<sub>a<\/sub><i>O<\/i><sub>2<\/sub>\/F<sub>i<\/sub><i>O<\/i><sub>2<\/sub> ratio 168 \u00b1 63). A total of 35 bronchoaspirates, 21 protected brushings, 11 bronchoalveolar lavages and 8 bronchial biopsies were done. The cardiorespiratory variables at the start and end of FB were: S<sub>a<\/sub><i>O<\/i><sub>2<\/sub> 93 \u00b1 3 to 94 \u00b1 5%, heart rate 95 \u00b1 17 to 99 \u00b1 22 b.p.m. and respiratory rate 24 \u00b1 11 to 25 \u00b1 11 respirations\/min. The lowest S<sub>a<\/sub><i>O<\/i><sub>2<\/sub> value reached during the procedure was 86 \u00b1 3% and the maximal ET<i>C<\/i><i>O<\/i><sub>2<\/sub> rise was 41 \u00b1 4 mm Hg. Leakage was <50 ml\/s in 32 patients. The clinical course was favorable in 66%. Invasive ventilation was necessary in 11%, 5 \u00b1 4 days after FB. Twelve patients (33%) died 3 \u00b1 2 days after FB as a result of their underlying disease. <i>Conclusions:<\/i> The system allowed to perform FB safely in patients with ARF. Although there is a relatively high rate of intubation and invasive mechanical ventilation due to illness severity, there was no worsening of oxygenation or complications attributable to the procedure.<\/jats:p>","DOI":"10.1159\/000314074","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T06:58:42Z","timestamp":1272437922000},"page":"321-326","source":"Crossref","is-referenced-by-count":23,"title":["Fiberoptic Bronchoscopy during Nasal Non-Invasive Ventilation in Acute Respiratory Failure"],"prefix":"10.1159","volume":"80","author":[{"given":"E.","family":"Chiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.N.","family":"Sancho-Chust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Llombart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Senent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Camarasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Signes-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,4,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.283.2.235"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200102153440703"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001340101063"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001340050763"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2809%2960496-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000192790"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc6830"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01752971"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-006-0129-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000151656"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.110.3.724"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.121.4.1149"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.05.00055705"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/314074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/314074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:17:21Z","timestamp":1745435841000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000314074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000314074","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}