{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:20:25Z","timestamp":1772223625668,"version":"3.50.1"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt;The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined. We investigated the involvement of Th2 cytokines in Ni-induced contact hypersensitivity reaction using GATA-3 transgenic (Tg) mice. &lt;i&gt;Methods:&lt;\/i&gt; A Ni-titanium (Ti) alloy was implanted under the skin of GATA-3 Tg mice. A Ni solution was then injected 1 month after sensitization. The ear swelling response was measured at several time points after the injection; the cytokine levels in the skin were measured at 48 h after injection, and the serum levels of IgE were measured 1 month after injection. In addition, purified CD4+ splenic cells obtained from the GATA-3 Tg mice sensitized with the Ni-Ti alloy were infused into Rag-2&lt;sup&gt;\u2013\/\u2013&lt;\/sup&gt; mice, and the ear swelling response of these mice after a further challenge with Ni solution was also measured. &lt;i&gt;Results:&lt;\/i&gt;Marked ear swelling and elevated serum IgE levels and skin tissue levels of IL-4 were observed in Ni-Ti-sensitized GATA-3 Tg mice. The Rag-2&lt;sup&gt;\u2013\/\u2013&lt;\/sup&gt; mice transfused with the CD4+ splenic cells from the Ni-Ti alloy sensitized GATA-3 Tg mice showed a significantly more pronounced ear swelling response than the control mice. &lt;i&gt;Conclusion:&lt;\/i&gt; We confirmed the participation of Th2-type immune reactions in Ni-induced allergy using GATA-3 Tg mice.<\/jats:p>","DOI":"10.1159\/000314372","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T07:28:17Z","timestamp":1274340497000},"page":"303-314","source":"Crossref","is-referenced-by-count":25,"title":["Th2 Immune Response Plays a Critical Role in the Development of Nickel-Induced Allergic Contact 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