{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T03:12:03Z","timestamp":1769915523451,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Introduction:<\/i> Lifelong premature ejaculation (LPE) is characterized by persistently shorter intravaginal ejaculation latency time (IELT) than found acceptable by the patient or his partner. It has been postulated to be a neurobiological dysfunction with genetic vulnerability and is related to disturbances of central serotonin (5-hydroxytryptamine, 5-HT) neurotransmission and 5-HT receptor function. <i>Aim:<\/i> To investigate the relationship between the C\u2013759T and G\u2013697C polymorphisms of the 5-HT<sub>2C<\/sub> receptor and LPE. <i>Methods:<\/i> A prospective study was conducted in 106 Han Chinese men with LPE, characterized by IELT of less than 1 min, and 84 healthy controls with IELT of more than 3 min. All subjects were genotyped for the C\u2013759T and G\u2013697C polymorphisms located in the promoter region of the 5-HT<sub>2C<\/sub> receptor. The frequencies of genotypes and single nucleotide mutations were compared between the two groups. <i>Results:<\/i> Three genotypes were detected both in the men with LPE and in the control group: \u2013759C\/\u2013697G, \u2013759T\/\u2013697C, and \u2013759C\/ \u2013697C. Genotype \u2013759T\/\u2013697G was not detected. The frequency of genotype \u2013759T\/\u2013697C was higher in patients with LPE than in the control group (30.2 vs. 11.9%, p < 0.05), whereas the frequency of genotype \u2013759C\/\u2013697G was lower in patients with LPE than in the control group (66.0 vs. 83.3%, p < 0.05). No difference was found for genotype \u2013759C\/ \u2013697C between the two groups. Mutations at \u2013759T and \u2013697C were more frequent in patients than in the control group (\u2013759T: 30.2 vs. 13.3%, p < 0.05; \u2013697C: 30.4 vs. 16.7%, p < 0.05, respectively). <i>Conclusions:<\/i> Our findings indicated that polymorphisms in the 5-HT<sub>2C<\/sub> receptor gene are associated with LPE, and men who carry the \u2013759T or \u2013697C genotype have increased odds of premature ejaculation. Further investigation in this field is necessary.<\/jats:p>","DOI":"10.1159\/000314528","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T07:45:15Z","timestamp":1285141515000},"page":"204-208","source":"Crossref","is-referenced-by-count":32,"title":["Association between Polymorphisms in the Serotonin 2C Receptor Gene and Premature Ejaculation in Han Chinese Subjects"],"prefix":"10.1159","volume":"85","author":[{"given":"Shunwen","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sixiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijir.3901099"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200212000-00004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-4328%2897%2900183-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097%2F00041444-199800810-00007"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neubiorev.2006.01.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fijir.2008.61"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2008.00901.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijir.3900472"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2008.01033.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001250050056"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2006.08.022"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F00041444-199800810-00007"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-3908%2895%2900138-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2899%2900086-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02246293"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-3908%2890%2990133-C"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2893%2990179-L"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2899%2900010-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F1.9.681"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001052"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2Faja.2008.3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.juro.2009.01.105"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/314528","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/314528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:21:44Z","timestamp":1745436104000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000314528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,9,1]]},"published-print":{"date-parts":[[2010,9,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000314528","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}