{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:45:51Z","timestamp":1773855951165,"version":"3.50.1"},"reference-count":45,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T00:00:00Z","timestamp":1274400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T00:00:00Z","timestamp":1274400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Aim:&lt;\/i&gt; This study evaluated the impact of hyperuricemia (HUR) on outcome in patients with different types of impaired renal function (IRF) and acute myocardial infarction (AMI) treated invasively. &lt;i&gt;Methods:&lt;\/i&gt; Out of 3,593 consecutive AMI patients treated invasively, 1,015 IRF patients were selected. The IRF group consisted of patients with baseline kidney dysfunction (BKD group) and\/or patients with contrast-induced nephropathy (CIN group). HUR was defined as a serum uric acid concentration (SUAC) &gt;420 \u00b5mol\/l (&gt;7 mg\/dl). Independent predictors of death and major adverse cardiovascular events (MACE) were selected by the multivariate Cox-regression model. &lt;i&gt;Results:&lt;\/i&gt; Remote mortality rates were higher in HUR patients: IRF (32.7 vs. 18.6%), BKD (41.3 vs. 25.9%), CIN (35.4 vs. 16.7%); all p &lt; 0.001. HUR was an independent predictor of death in BKD (hazard ratio (HR) 1.38, p &lt; 0.05). Each 100-\u00b5mol\/l increase in SUAC was associated with a significant increase of HR for mortality: 1.087 in IRF patients, 1.108 in BKD patients, 1.128 in CIN patients; all p &lt; 0.05. Remote major adverse cardiovascular event rates were higher in HUR patients: IRF (55.4 vs. 48.9%), CIN (56.8 vs. 48%); both p &lt; 0.05. &lt;i&gt;Conclusions:&lt;\/i&gt; In AMI patients treated invasively, an increase in SUAC is an independent predictor of death within all types of renal dysfunction; HUR defined as SUAC &gt;420 \u00b5mol\/l (&gt;7 mg\/dl) is a predictor only in BKD patients.<\/jats:p>","DOI":"10.1159\/000314660","type":"journal-article","created":{"date-parts":[[2010,5,21]],"date-time":"2010-05-21T07:19:37Z","timestamp":1274426377000},"page":"c114-c122","source":"Crossref","is-referenced-by-count":27,"title":["Prognostic Significance of Hyperuricemia in Patients with Different Types of Renal Dysfunction and Acute Myocardial Infarction Treated with Percutaneous Coronary 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