{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T15:03:53Z","timestamp":1783091033327,"version":"3.54.6"},"reference-count":28,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; To evaluate the association between serum cystatin C and homocysteine concentrations, cardiovascular risk factors and cardiovascular events in hypertensive patients with coronary artery disease (CAD). &lt;i&gt;Methods:&lt;\/i&gt; 260 patients with hypertension and CAD (mean age 56.9 \u00b1 9.3) were included. During a mean 40-month follow-up the combined end-point of death from all causes, non-fatal myocardial infarction and stroke or coronary revascularization was assessed. &lt;i&gt;Results:&lt;\/i&gt; Subjects in the highest serum cystatin C quartile (&gt;103.4 nmol\/l) as compared with the lowest were older, were characterized by a higher frequency of multivessel CAD, higher levels of homocysteine (13.2 \u00b1 5.2 vs. 11.4 \u00b1 4.2 \u00b5mol\/l; p &lt; 0.01), fibrinogen and high-sensitivity C-reactive protein and by an increased intima-media thickness. Combined end-point occurred twice as frequently in the 4th quartile of serum cystatin C as compared with the 1st quartile (10.8 vs. 20.3%; p = 0.11). In an univariate analysis, but not in a multivariate model, cystatin C concentration predicted the combined end-point (Exp(B) = 1.096; p &lt; 0.05). &lt;i&gt;Conclusion:&lt;\/i&gt; In hypertensive patients with CAD, serum cystatin C level was independently associated with the extent of CAD, homocysteine plasma level and traditional vascular risk factors. However, serum cystatin C concentration did not independently predict the combined end-point.<\/jats:p>","DOI":"10.1159\/000314812","type":"journal-article","created":{"date-parts":[[2010,5,28]],"date-time":"2010-05-28T09:24:26Z","timestamp":1275038666000},"page":"139-148","source":"Crossref","is-referenced-by-count":5,"title":["Reduced Kidney Function Estimated by Cystatin C and Clinical Outcomes in Hypertensive Patients with Coronary Artery Disease: Association with Homocysteine and Other Cardiovascular Risk 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