{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:02:32Z","timestamp":1790514152607,"version":"4.1.0"},"reference-count":5,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background and Methods:&lt;\/i&gt; To evaluate the value of brain biopsy for neurology patients in our unit, we conducted a retrospective audit of neurology patients referred for brain biopsies for non-neoplastic disease from 1993 to 2007. &lt;i&gt;Results:&lt;\/i&gt; 64 patients [median (range) age 51 (16\u201374) years] were included. The clinical presentation was diffuse encephalopathy for 40 patients, focal for 13 and multifocal for 11. The biopsy was diagnostic in 34 patients, abnormal but non-diagnostic in 21 and normal in 9. There was a statistically significant association between clinical presentation and biopsy result (p = 0.004); diagnostic biopsies were more common in patients with focal or multifocal clinical presentations. Twenty patients (31%) had alterations of management as a result of their brain biopsy, comprising specific treatment (11 patients) or prognosis\/diagnosis of untreatable conditions (9 patients). Diagnoses of treatable conditions included Whipple\u2019s disease, tuberculoma, progressive multifocal leukoencephalopathy, and neurosarcoidosis. Five patients (7.8%) had complications. &lt;i&gt;Conclusions:&lt;\/i&gt; Brain biopsy is useful and relatively safe in the management of neurology patients, with a diagnostic yield of 53% in our series; some led to significant changes in management, including treatment of infections. Patients with focal or multifocal presentation are more likely to yield a diagnostic biopsy result.<\/jats:p>","DOI":"10.1159\/000315032","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T06:58:29Z","timestamp":1278313109000},"page":"42-45","source":"Crossref","is-referenced-by-count":26,"title":["Brain Biopsy in the Management of Neurology Patients"],"prefix":"10.1159","volume":"64","author":[{"given":"S.H.","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Jenkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Faragher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Crooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Solomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00006123-199710000-00011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1227%2F00006123-197902000-00004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1227%2F01.neu.0000318168.97966.17"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawh543"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.73.3.336"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:26:03Z","timestamp":1745436363000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000315032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":5,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,7,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000315032","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}