{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:00:41Z","timestamp":1774119641213,"version":"3.50.1"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T00:00:00Z","timestamp":1274486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,5,22]],"date-time":"2010-05-22T00:00:00Z","timestamp":1274486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background:<\/i> Some individuals with moderate\/severe persistent asthma develop irreversible airway obstruction. These individuals present with dyspnoea, exercise intolerance and impaired quality of life (QOL), all of which could potentially be alleviated with exercise training. <i>Objective:<\/i> To investigate whether exercise training improves functional exercise capacity and QOL in middle-aged and older adults with fixed airway obstruction asthma (FAOA). <i>Methods:<\/i> 35 subjects aged 67.8 \u00b1 10.6 years, with FEV<sub>1<\/sub> 59 \u00b1 16% of predicted, were randomised to a 6-week \u2018intervention\u2019 period of supervised exercise training (n = 20) or usual care (n = 15). This period was preceded by a 3-week run-in period during which asthma control was assessed weekly. Functional exercise capacity (6-min walk distance, 6MWD) and QOL (Asthma QOL Questionnaire, AQLQ) were measured before, immediately following and 3 months after the intervention period. <i>Results:<\/i> 34 subjects (exercise group, n = 19, and control group, n = 15) completed the intervention period. Relative to the control group, the exercise group had greater improvements immediately following and 3 months after the intervention in the AQLQ symptom domain (0.61, p = 0.001, and 0.57 points per item, p = 0.005) and AQLQ activity limitation domain (0.43, p = 0.04, and 0.55 points per item, p = 0.04). 6MWD increased (36 \u00b1 37 m, p < 0.01) in the exercise group immediately following training and remained elevated (34 \u00b1 45 m, p < 0.01) at the 3-month follow-up. The magnitude of change in 6MWD between groups was not significant, despite no change in the control group. <i>Conclusions:<\/i> Supervised exercise training improves symptoms and QOL in adults with FAOA.<\/jats:p>","DOI":"10.1159\/000315142","type":"journal-article","created":{"date-parts":[[2010,5,26]],"date-time":"2010-05-26T07:02:08Z","timestamp":1274857328000},"page":"302-310","source":"Crossref","is-referenced-by-count":108,"title":["Improvements in Symptoms and Quality of Life following Exercise Training in Older Adults with Moderate\/Severe Persistent Asthma"],"prefix":"10.1159","volume":"81","author":[{"given":"Sian","family":"Turner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eastwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angus","family":"Cook","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1081%2FJAS-100000107"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.43.10.745"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.02.02542001"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.04.00064204"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2800%2990057-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.112.5.1234"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00000441-200210000-00002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177%2F1479972307084446"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.120.1.88"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.123.5.1394"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.47.2.76"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1399-3003.1999.14d29.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164%2Frccm.200508-1211ST"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0447.1983.tb09716.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-9993%2897%2990005-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0895-4356%2894%2990036-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.99.13112599"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-2456%2800%2900046-5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-2418"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.97.10010104"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fthx.45.5.345"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00140507"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.apmr.2008.01.020"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:26:58Z","timestamp":1745436418000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000315142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,22]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000315142","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,22]]}}}