{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:14:59Z","timestamp":1777652099583,"version":"3.51.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Two hundred fungal isolates (Aspergillus and Fusarium species) from mycotic keratitis were tested for in vitro susceptibilities to amphotericin B and proteinase production. Geometric mean MICs for all fungal species increased fourfold with thousandfold increase in the inoculum. The MIC&lt;sub&gt;50&lt;\/sub&gt; and MIC&lt;sub&gt;90&lt;\/sub&gt; values ranged between 3.12\u20136.25 and 3.12\u201312.5 \u00b5g\/ml, respectively. Proteinase production was noted in 113 (56.5%) isolates. Ninety-eight (49%) showed MICs of \u22671.56 \u00b5g\/ml that was above the criteria of \u22671 \u00b5g\/ml for amphotericin B resistance (CLSI). Seventy-three (74.5%) of these 98 isolates were proteinase producers, whereas only 40 (39.2%) of the remaining 102 with low MICs (&lt;1.56 \u00b5g\/ml) were proteinase producers (p &lt; 0.001). Proteinase seems to be an important virulence marker of filamentous fungi in mycotic keratitis, correlating significantly with amphotericin B resistance.<\/jats:p>","DOI":"10.1159\/000315360","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T07:03:11Z","timestamp":1275462191000},"page":"113-118","source":"Crossref","is-referenced-by-count":9,"title":["Correlation of Proteinase Production with Amphotericin B Resistance in Fungi from Mycotic Keratitis"],"prefix":"10.1159","volume":"44","author":[{"given":"N.","family":"Nayak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Satpathy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sujata","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.B.","family":"Vajpayee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000129413"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00437209"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.125.6.789"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4103%2F0255-0857.29386"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315360","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315360","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:29:26Z","timestamp":1745436566000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000315360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":4,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,7,1]]},"published-print":{"date-parts":[[2010,7,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000315360","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}