{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:05:30Z","timestamp":1760983530346,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Visual hallucinations are a core feature of dementia with Lewy bodies (DLB) and have been proposed as being part of a narcolepsy-like REM sleep disorder. Selective loss of hypothalamic hypocretin-producing neurons is common to both narcolepsy and the spectrum of Lewy body diseases. We hypothesized that the genetic marker associated with narcolepsy, the HLA class II DR2-DQ6 haplotype, could confer some degree of susceptibility to brainstem-hypothalamic damage leading to the manifestation of visual hallucinations. &lt;i&gt;Methods:&lt;\/i&gt; We examined HLA class II haplotypes in 30 patients with prominent visual hallucinations in the context of clinical criteria for DLB and in 30 patients affected by a cortical-type dementia without hallucinations. &lt;i&gt;Results:&lt;\/i&gt; No significant differences were found in the distribution of DR and DQ antigens. &lt;i&gt;Conclusions:&lt;\/i&gt; We conclude that hypothalamic vulnerability in different diseases is not mediated by a common HLA haplotype.<\/jats:p>","DOI":"10.1159\/000315545","type":"journal-article","created":{"date-parts":[[2010,7,5]],"date-time":"2010-07-05T06:58:29Z","timestamp":1278313109000},"page":"8-11","source":"Crossref","is-referenced-by-count":1,"title":["Visual Hallucinations and HLA Class II Antigens in Cortical Dementia"],"prefix":"10.1159","volume":"30","author":[{"given":"Estrella","family":"G\u00f3mez-Tortosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Aguerri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Jos\u00e9","family":"Sainz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mireya","family":"Losada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro J.","family":"Garc\u00eda-Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"C\u00e1rdaba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000187889.17253.b1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2806%2970476-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sleep.2007.03.008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm090"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm097"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FJGP.0b013e3181953b9a"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181b2a6af"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.6.817"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molimm.2006.03.007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.10409"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawm132"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000132084"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawp295"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000111549"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000077816"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.21077"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315545","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315545","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:31:50Z","timestamp":1745436710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000315545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,8,1]]},"published-print":{"date-parts":[[2010,8,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000315545","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2010]]}}}