{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:13:00Z","timestamp":1761109980946,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; This observational study was conducted to document the efficacy and safety of the use of micafungin (Mycamine) as an empirical antifungal agent in febrile neutropenic patients. &lt;i&gt;Methods:&lt;\/i&gt; Micafungin was administered for sustained fever (&gt;38.4\u00b0C) on days 3\u20135 following the initiation of empirical antibiotic therapy. The overall success rate and side effects were evaluated. &lt;i&gt;Results:&lt;\/i&gt; A total of 47 patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome and lymphoma were enrolled in the study. The overall success rate of micafungin was 61.7% (29\/47). A total of 3 patients (6.4%) experienced grade 3\/4 elevations in their aspartate aminotransferase levels, and 10 patients (21%) experienced grade 3\/4 hyperbilirubinemia, 9 of which resolved. Four patients died of septic shock. Younger patients (&lt;50 years) and patients with acute lymphoblastic leukemia exhibited a better response to micafungin than other patients. Patients that were less profoundly neutropenic (\u22670.05 \u00d7 10&lt;sup&gt;9&lt;\/sup&gt;\/l) also had a better response to micafungin, as did the patients who recovered from their fever or neutropenia. &lt;i&gt;Conclusion:&lt;\/i&gt; Micafungin has an excellent efficacy (61.7%) and safety profile when used as an empirical antifungal agent in febrile neutropenic patients with hematological disorders.<\/jats:p>","DOI":"10.1159\/000315558","type":"journal-article","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T07:03:20Z","timestamp":1279695800000},"page":"92-97","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy and Safety of Micafungin as an Empirical Antifungal Agent for Febrile Neutropenic Patients with Hematological Diseases"],"prefix":"10.1159","volume":"124","author":[{"given":"Joon Seong","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Hyun","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Hyuk","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Won","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok-Hwan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun Ho","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,7,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819920601%2969%3A11%3C2653%3A%3AAID-CNCR2820691106%3E3.0.CO%3B2-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2881%2990586-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2007.06812.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-1161"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.10.3149-3154.2003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.44.1.57-62.2000"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086%2F588660"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199903113401004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2899%2900457-X"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa040446"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2133%2Fdmpk.18.48"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F00365540410020406"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2960605-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10096-005-0024-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086%2F520980"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F10428190802635500"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200201243460403"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:31:58Z","timestamp":1745436718000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000315558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,10,1]]},"published-print":{"date-parts":[[2010,10,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000315558","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2010]]}}}