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Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>A rare case of oromandibular &lt;i&gt;Rhizopus oryzae&lt;\/i&gt; infection is described in a 55-year-old woman with acute myeloid leukaemia and decompensated diabetes mellitus. The infection developed during induction chemotherapy when the patient was neutropenic. She was treated with a combination of amphotericin B lipid formulation and caspofungin plus surgery. Debridement surgery included excision of the lower lip, chin, floor of the mouth, a portion of the tongue, as well as mandibular resection at the level of the horizontal branches. Eight weeks of combined antifungal therapy were followed by secondary prophylaxis with amphotericin B lipid formulation during consolidation chemotherapy after achieving complete response of both leukaemia and mucormycosis. Reconstructive surgery was carried out including insertion of a new biomaterial porous mandibular prosthesis, which showed excellent functionality after long-term follow-up, followed by several plastic surgery procedures once good tolerability and no adverse effects of the prosthesis were observed. This case shows that a well-coordinated multidisciplinary approach is critical to increase the chances of clinical success in this life-threatening infection.<\/jats:p>","DOI":"10.1159\/000315675","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T07:26:45Z","timestamp":1280820405000},"page":"98-102","source":"Crossref","is-referenced-by-count":17,"title":["Lessons from a Case of Oromandibular Mucormycosis Treated with Surgery and a Combination of Amphotericin B Lipid Formulation plus Caspofungin"],"prefix":"10.1159","volume":"124","author":[{"given":"Mario","family":"Ojeda-Uribe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Herbrecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie H\u00e9l\u00e8ne","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Chain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre","family":"Chenard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marie","family":"Servant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Debry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086%2F599105"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-5520%2802%2900037-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F432579"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.43.4.2012-2014.2005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1086%2F516353"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086%2F589857"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.45.12.3487-3496.2001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.00452-07"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.50.1.126-133.2006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.49.2.830-832.2005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.49.2.721-727.2005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000068657"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.00595-07"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0030-4220%2893%2990170-9"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9343%2803%2900092-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-4975%2894%2990243-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2802%2903569-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00006534-199505000-00010"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315675","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/315675","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:32:40Z","timestamp":1745436760000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000315675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,10,1]]},"published-print":{"date-parts":[[2010,10,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000315675","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2010]]}}}