{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:37:57Z","timestamp":1745469477044,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Background:<\/i> The Aga Khan University Hospital is a tertiary care centre in Karachi, Pakistan, where tigecycline has not been used previously. We report findings of a pre-use in vitro study to evaluate sensitivity of nosocomial <i>Acinetobacter <\/i>spp. Tigecycline minimum inhibitory concentration (MIC) was correlated with that of other tetracyclines to assess their predictive potential. <i>Methods:<\/i><i>Acinetobacter <\/i>spp. were collected from hospitalized inpatients admitted to Aga Khan University Hospital from April to November 2007. Tigecycline, tetracycline, doxycycline, and minocycline MICs were determined by E-test. <i>Results:<\/i> One hundred isolates of <i>Acinetobacter <\/i>spp. were tested. Ninety-eight percent of <i>Acinetobacter <\/i>spp. were carbapenem-resistant. Tigecycline MIC<sub>50<\/sub> and MIC<sub>90<\/sub> were 1.5 and 2.0 \u00b5g\/ml, respectively. Unavailability of standard breakpoints hindered categorization of these values. Minocycline was highly active, with MIC<sub>90<\/sub> of 2.0 \u00b5g\/ml. <i>Conclusions:<\/i> Tigecycline breakpoints for <i>Acinetobacter <\/i>spp. should be established to prevent injudicious use of this antibiotic based on misleading in vitro results. The therapeutic potential of minocycline needs more in-depth study.<\/jats:p>","DOI":"10.1159\/000316328","type":"journal-article","created":{"date-parts":[[2010,6,10]],"date-time":"2010-06-10T06:46:32Z","timestamp":1276152392000},"page":"184-189","source":"Crossref","is-referenced-by-count":6,"title":["In vitro Activity of Tigecycline and Other Tetracyclines against Carbapenem-Resistant <i>Acinetobacter <\/i>Species: Report from a Tertiary Care Centre in Karachi, Pakistan"],"prefix":"10.1159","volume":"56","author":[{"given":"Sadia","family":"Shakoor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erum","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afia","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rumina","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,6,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1086%2F502205"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000007226"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F499819"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.diagmicrobio.2005.05.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.11.4479-4481.2004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkm018"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkn165"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkl383"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000118660"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000167788"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1086%2F526775"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkl441"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.02464-08"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkp169"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086%2F588051"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.00089-07"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkn172"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-003-1811-2"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.01099-06"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/316328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/316328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:38:34Z","timestamp":1745437114000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000316328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000316328","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2010]]}}}