{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:36:52Z","timestamp":1745469412694,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T00:00:00Z","timestamp":1276041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T00:00:00Z","timestamp":1276041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Direct hemoperfusion with a polymyxin B-immobilized fiber column (PMX-DHP) has been shown to improve oxygenation in cases of diffuse alveolar damage, but little is known about its effectiveness in treating pneumocystis pneumonia (PCP) in HIV-negative immunosuppressed patients. &lt;i&gt;Objectives:&lt;\/i&gt; This study was aimed at investigating the effect of PMX-DHP in treating non-HIV-related PCP. &lt;i&gt;Methods:&lt;\/i&gt; Between October 2005 and September 2008, 6 patients with non-HIV-related PCP were treated with 2 sessions of PMX-DHP at an attending physician\u2019s discretion when severe hypoxemia developed despite conventional treatments including high-dose corticosteroid, whereas 9 patients in a similar condition were treated without PMX-DHP. Changes in oxygenation and radiographic findings in the PMX-DHP group and adverse events associated with PMX-DHP were investigated retrospectively, as were the outcomes for both treatment groups. &lt;i&gt;Results:&lt;\/i&gt; There was an improvement in PaO&lt;sub&gt;2&lt;\/sub&gt;\/FiO&lt;sub&gt;2&lt;\/sub&gt; during each PMX-DHP session, from 148.8 \u00b1 52.5 to 188.2 \u00b1 79.3 mm Hg (p = 0.02). After 2 sessions of PMX-DHP, an improvement in PaO&lt;sub&gt;2&lt;\/sub&gt;\/FiO&lt;sub&gt;2&lt;\/sub&gt;, from 131.8 \u00b1 37.4 to 213.3 \u00b1 87.3 mm Hg, was observed (p = 0.04), but no significantly different improvement was detected on the following day. The radiographic findings improved in 4 patients during PMX-DHP. The in-hospital mortality was similarly high in both groups (50% in the PMX-DHP group vs. 67% in the non-PMX-DHP group). No significant adverse events associated with PMX-DHP were observed except for advanced thrombocytopenia in 1 patient. &lt;i&gt;Conclusion:&lt;\/i&gt; PMX-DHP may serve as an adjunct in the treatment of non-HIV-related PCP, temporarily alleviating severe hypoxemia even in cases refractory to conventional treatments.<\/jats:p>","DOI":"10.1159\/000316340","type":"journal-article","created":{"date-parts":[[2010,6,9]],"date-time":"2010-06-09T07:11:28Z","timestamp":1276067488000},"page":"318-324","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic Effect of Direct Hemoperfusion with a Polymyxin B-Immobilized Fiber Column in the Treatment of HIV-Negative Severe Pneumocystis Pneumonia"],"prefix":"10.1159","volume":"81","author":[{"given":"Ryo","family":"Tachikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Tomii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimihiko","family":"Murase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyosuke","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,6,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.118.3.704"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1086%2F313534"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra032588"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc6806"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199011223232104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.113.5.1215"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086%2F598651"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc5780"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.2009.856"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1526-0968.2003.00005.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fjca.10019"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186%2Fcc3815"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2169%2Finternalmedicine.45.6018"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1843.2008.01290.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000078494"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2006.00339.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200102153440703"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2FSHK.0b013e3181a2a978"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.08-1309"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.06-1467"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/316340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/316340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:16:48Z","timestamp":1745435808000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000316340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,9]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000316340","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2010,6,9]]}}}