{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:35:04Z","timestamp":1791408904041,"version":"4.3.3"},"reference-count":38,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Congenital diaphragmatic hernia (CDH) is associated with a mortality rate of 10\u201335% in live-born infants. Moreover, CDH survivors have a substantial risk of developing long-term pulmonary sequelae, such as bronchopulmonary dysplasia (BPD). &lt;i&gt;Objectives:&lt;\/i&gt; This study aims to evaluate risk factors associated with BPD and mortality in neonates with CDH, with particular focus on the initial ventilation mode. &lt;i&gt;Methods:&lt;\/i&gt; Eligible for inclusion were live-born infants with CDH born from 2001 through 2006 at the centers participating in the CDH Study Group. BPD (defined as oxygen dependency at day 30) and\/or mortality by day 30 served as the primary endpoint. &lt;i&gt;Results:&lt;\/i&gt; A total of 2,078 neonates were included in the analysis. At day 30, 56% of the patients had either died or met the criteria for BPD. In infants who survived until day 30, the prevalence of BPD was 41%. The overall mortality rate was 31%. High-frequency oscillatory ventilation as initial ventilation mode, a right-sided defect, a prenatal diagnosis, a lower Apgar score at 5 min, a cardiac anomaly, a chromosomal anomaly and a lower gestational age were all associated with BPD and\/or mortality by day 30. &lt;i&gt;Conclusions:&lt;\/i&gt; Despite improvements in neonatal care, the rates of BPD and early mortality in newborns with CDH are still considerable. Several important risk factors for a worse outcome are reported in this nonrandomized prospective observational study.<\/jats:p>","DOI":"10.1159\/000316974","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T08:04:05Z","timestamp":1288598645000},"page":"370-380","source":"Crossref","is-referenced-by-count":93,"title":["Risk Factors for Chronic Lung Disease and Mortality in Newborns with Congenital Diaphragmatic Hernia"],"prefix":"10.1159","volume":"98","author":[{"given":"L.","family":"van den 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