{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:33:57Z","timestamp":1791182037695,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; The present study investigated the relationship between mast cells (MCs) and the protein expression of stem cell factor (SCF) and transforming growth factor-\u03b2&lt;sub&gt;1&lt;\/sub&gt; (TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt;) in the regions of renal interstitial fibrosis with protein-overload nephropathy, in order to provide a good animal model to study the mechanism of renal fibrosis induced by proteinuria. &lt;i&gt;Methods:&lt;\/i&gt; 60 male Sprague-Dawley rats were divided into a bovine serum albumin (BSA) group and a control group. The intensity of MCs infiltration was examined by toluidine blue and chymase and tryptase staining. The protein expression of SCF and TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt; was respectively examined by immunohistochemical and immunofluorescence staining. &lt;i&gt;Results:&lt;\/i&gt; Severe proteinuria was induced in rats of the BSA group. Expression of SCF and TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt; was detected in the tubular and the interstitial cells. The number of MCs positively correlated with the severity of interstitial lesions and the expression of SCF and TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt;. &lt;i&gt;Conclusion:&lt;\/i&gt; Our results demonstrated that in protein-overload nephropathy, MCs infiltrated into the kidney, and the expression of SCF and TGF-\u03b2&lt;sub&gt;1&lt;\/sub&gt; gradually increased. They might play important roles in the development of renal interstitial fibrosis, but the underlying mechanism needs to be further studied.<\/jats:p>","DOI":"10.1159\/000317102","type":"journal-article","created":{"date-parts":[[2010,6,25]],"date-time":"2010-06-25T07:06:05Z","timestamp":1277449565000},"page":"240-248","source":"Crossref","is-referenced-by-count":18,"title":["Mast Cell Infiltration Is Involved in Renal Interstitial Fibrosis in a Rat Model of Protein-Overload Nephropathy"],"prefix":"10.1159","volume":"33","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuyou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youming","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghui","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuncheng","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.90521.2008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.09915.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.arcmed.2006.05.013"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.425"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-065X.2007.00503.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1472-8206.2005.00390.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2008010015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mehy.2006.10.059"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000112850"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0272-6386%2895%2990165-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yexmp.2005.11.005"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2353%2Fajpath.2007.060937"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm694"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00374.2007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00011-007-6145-z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-008-1044-2"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.09220.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1385%2FIR%3A34%3A2%3A97"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2008-03-147033"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000112518"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00183.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2007101080"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:23:19Z","timestamp":1745436199000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000317102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000317102","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}