{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:31Z","timestamp":1787017891798,"version":"build-2736575974"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T00:00:00Z","timestamp":1278028800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Chronic kidney disease (CKD) is associated with increased risk of fragility fracture but whether this is independent of osteoporosis is unclear. &lt;i&gt;Methods:&lt;\/i&gt; We conducted a retrospective cross-sectional study of 1,702 female patients referred for dual-energy X-ray absorptiometry (DXA) scanning (Lunar IDXA) between September 2006 and April 2007. Estimated glomerular filtration rate (eGFR; ml\/min\/1.73 m&lt;sup&gt;2&lt;\/sup&gt;) by Modification of Diet in Renal Disease was calculated within 1 year (median interval 4 weeks) of the DXA scan. The independent association of self-reported fracture occurrence with eGFR category was assessed using multivariate logistic regression. &lt;i&gt;Results:&lt;\/i&gt; Mean age (SD) was 61.7 (10.8) years; mean eGFR (SD) was 68.8 (12.2). The percentages of subjects with an eGFR of 75\u201389, 60\u201374, 30\u201359 and &lt;30 was 34, 45, 20 and 0.8%, respectively. Forty-seven percent had osteoporosis. Mean T scores for the above eGFR categories were \u20132.2, \u20132.3, \u20132.5 and \u20133.0, respectively (p trend &lt;0.001). Osteoporosis was significantly associated with eGFR on univariate analysis but not following adjustment for age. The percentage of patients with a fracture (29%) and with multiple prior fractures (3.5%) was higher at lower eGFR (p &lt; 0.001, \u03c7&lt;sup&gt;2&lt;\/sup&gt; test). The adjusted odds ratios (95% confidence interval) of any prior fracture for eGFR 75\u201389, 60\u201374 and 30\u201359 were 1.0 (reference), 1.2 (0.9\u20131.6) and 1.4 (1.0\u20131.9), respectively, adjusting simultaneously for age, T score, risk factors and treatment for osteoporosis. &lt;i&gt;Conclusion:&lt;\/i&gt; Moderate CKD is a significant independent predictor of fracture occurrence.<\/jats:p>","DOI":"10.1159\/000317207","type":"journal-article","created":{"date-parts":[[2010,7,2]],"date-time":"2010-07-02T02:50:08Z","timestamp":1278039008000},"page":"c256-c262","source":"Crossref","is-referenced-by-count":29,"title":["Moderate Chronic Kidney Disease in Women Is Associated with Fracture Occurrence Independently of Osteoporosis"],"prefix":"10.1159","volume":"116","author":[{"given":"Sinead","family":"Kinsella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn","family":"Chavrimootoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Eustace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,7,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.167.2.133"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2006050546"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-005-1903-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005111194"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2008.01807.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.08.019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.02.264"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.264"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.285.6.785"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2002.32799"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2003.12.004"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000414"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-139X.2007.00319.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2009.01.007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.162.12.1401"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00481.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1359%2Fjbmr.061014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-008-0608-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00306.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-007-0525-7"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn678"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:24:06Z","timestamp":1745421846000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000317207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,2]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000317207","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,2]]}}}