{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:47:30Z","timestamp":1780678050173,"version":"3.54.1"},"reference-count":34,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Innate Immun"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Group A &lt;i&gt;Streptococcus&lt;\/i&gt; (GAS) causes rare but life-threatening syndromes of necrotizing fasciitis and toxic shock-like syndrome in humans. The GAS serotype M1T1 clone has globally disseminated, and mutations in the control of virulence regulatory sensor kinase (&lt;i&gt;covRS)&lt;\/i&gt; operon correlate with severe invasive disease. Here, a cohort of non-M1 GAS was screened to determine whether mutation in &lt;i&gt;covRS&lt;\/i&gt; triggers systemic dissemination in divergent M serotypes. A GAS disease model defining parameters governing invasive propensity of differing M types is proposed. The vast majority of GAS infection is benign. Nonetheless, many divergent M types possess limited capacity to cause invasive infection. M1T1 GAS readily switch to a &lt;i&gt;covRS&lt;\/i&gt; mutant form that is neutrophil resistant and frequently associated with systemic infection. Whilst non-M1 GAS are shown in this study to less frequently accumulate &lt;i&gt;covRS&lt;\/i&gt; mutations in vivo, such mutants are isolated from invasive infections and exhibit neutrophil resistance and enhanced virulence. The reduced capacity of non-M1 GAS to switch to the hypervirulent &lt;i&gt;covRS&lt;\/i&gt; mutant form provides an explanation for the comparatively less frequent isolation of non-M1 serotypes from invasive human infections.<\/jats:p>","DOI":"10.1159\/000317640","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T14:38:04Z","timestamp":1283524684000},"page":"596-606","source":"Crossref","is-referenced-by-count":33,"title":["Parameters Governing Invasive Disease Propensity of Non-M1 Serotype Group A Streptococci"],"prefix":"10.1159","volume":"2","author":[{"given":"Peter G.","family":"Maamary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina L.","family":"Sanderson-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramy 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