{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T01:53:41Z","timestamp":1778550821680,"version":"3.51.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people has not been reported. &lt;i&gt;Methods:&lt;\/i&gt; Adult cases that received linezolid for bone and joint infections at 3 Taiwanese medical centers from 2002 to 2006 were analyzed. We investigated factors associated with treatment outcome and hematological adverse reactions. &lt;i&gt;Results:&lt;\/i&gt; Of the 51 cases that received linezolid for more than 3 days, 41 (80.4%) had a favorable outcome and 10 had a failed outcome. Based on univariate analysis, patients with renal\/urinary tract diseases, gastrointestinal diseases, higher WBC counts, a higher alanine aminotransferase level, or a higher creatinine level prior to linezolid treatment were significantly associated with a failed outcome. Based on multivariate analysis, underlying gastrointestinal disease was the only significant factor for a failed outcome. Six patients stopped linezolid use due to adverse reactions. A failed outcome was significantly associated with anemia caused by linezolid. &lt;i&gt;Conclusion:&lt;\/i&gt; Linezolid is an effective salvage agent for bone and joint infections. However, adverse effects, especially hematological reactions, may cause drug discontinuation.<\/jats:p>","DOI":"10.1159\/000317752","type":"journal-article","created":{"date-parts":[[2010,11,17]],"date-time":"2010-11-17T07:42:08Z","timestamp":1289979728000},"page":"429-435","source":"Crossref","is-referenced-by-count":10,"title":["Compassionate Use of Linezolid for Adult Taiwanese Patients with Bone and Joint Infections"],"prefix":"10.1159","volume":"56","author":[{"given":"Po-Liang","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jann-Tay","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Jung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan-Chin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tun-Chieh","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yhu-Chering","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan-Chwen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2006.08.030"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000223069"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000112312"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.12.3964-3966.2003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdki016"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FINF.0b013e31812e62dc"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086%2F381202"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2008.10.006"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.diagmicrobio.2007.04.006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.blo.0000144860.11193.5e"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs15010-004-3029-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4065%2F79.9.1137"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkh409"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1086%2F380449"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS1473-3099%2807%2970312-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkl219"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.6.1824-1831.2003"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1086%2F345744"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1086%2F340265"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1080%2F00365540701509873"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2006.01400.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkh199"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1089%2F109629603764655290"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjsurg.2005.01.011"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317752","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:29:39Z","timestamp":1745436579000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000317752"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000317752","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}