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Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The cost and effectiveness patterns in the treatment of secondary hyperparathyroidism (SHPT) in dialysis patients in the Czech Republic are unknown. &lt;i&gt;Methods:&lt;\/i&gt; 52 dialysis patients from 17 centers were followed up in a multicenter prospective study of laboratory and clinical (hospitalization rate, clinical complaints questionnaire) responses to 12-month cinacalcet treatment. Treatment patterns and cost (including phosphate binders, vitamin D, and cinacalcet) were evaluated. &lt;i&gt;Results:&lt;\/i&gt; The mean s-Ca dropped significantly from 2.36 \u00b1 0.24 to 2.21 \u00b1 0.20 mmol\/l, s-P from 2.45 \u00b1 0.54 to 2.01 \u00b1 0.53 mmol\/l, Ca\u00d7P from 5.79 \u00b1 1.25 to 4.42 \u00b1 1.13 mmol&lt;sup&gt;2&lt;\/sup&gt;\/l&lt;sup&gt;2&lt;\/sup&gt;, and iPTH dropped from 919.0 \u00b1 465.6 to 372.1 \u00b1 294.6 pg\/ml. The mean cinacalcet dose reached 44.1 \u00b1 23.0 mg\/day after 12 months. Itching intensity decreased significantly. No change in hospitalization rate was observed. The direct cost of daily SHPT treatment rose significantly from EUR 8.77 \u00b1 9.59 to 20.62 \u00b1 9.22. &lt;i&gt;Conclusions:&lt;\/i&gt; Cinacalcet decreased elevated s-Ca, s-P, Ca\u00d7P, and iPTH, alleviated itching, and significantly raised the SHPT treatment cost. A minority of patients reached K\/DOQI targets, especially due to poor phosphate control caused by insufficient phosphate binder treatment, cinacalcet underdosing, and advanced SHPT.<\/jats:p>","DOI":"10.1159\/000317935","type":"journal-article","created":{"date-parts":[[2010,8,12]],"date-time":"2010-08-12T07:22:42Z","timestamp":1281597762000},"page":"333-342","source":"Crossref","is-referenced-by-count":6,"title":["Cinacalcet \u2013 Clinical and Laboratory Effectiveness, Concomitant Treatment Patterns and Treatment Cost: Could We Do Better and How?"],"prefix":"10.1159","volume":"33","author":[{"given":"Jana","family":"Smr\u017eov\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Urb\u00e1nek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fndtplus%2Fsfm037"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000133041.27682.A2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000073945"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.7.4040"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fndtplus%2Fsfm039"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031633"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn654"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndtplus%2Fsfm038"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.07308.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl840"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.05241008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfp144"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.67139.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh966"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000101727"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.03591006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.01060308"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajkd.2003.06.001"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.67103.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.03.009"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.04381206"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fndtplus%2Fsfm042"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/317935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:31:34Z","timestamp":1745436694000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000317935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000317935","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"type":"print","value":"1420-4096"},{"type":"electronic","value":"1423-0143"}],"subject":[],"published":{"date-parts":[[2010]]}}}