{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:28:08Z","timestamp":1769812088129,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Anti-tumor necrosis factor (TNF) agents are increasingly being used for a rapidly expanding number of rheumatic and systemic diseases. As a result of this use, and of the longer follow-up periods of treatment, there are a growing number of reports of the development of autoimmune processes related to anti-TNF agents. The use of anti-TNF agents has been associated with more and more cases of autoimmune diseases, principally cutaneous vasculitis, lupus-like syndrome, systemic lupus erythematosus and interstitial lung disease. &lt;i&gt;Observations:&lt;\/i&gt; We report 2 cases of autoimmune bullous skin disease occurring in patients undergoing TNF-targeted therapy: a bullous pemphigoid and a pemphigus foliaceus. Both patients were treated by anti-TNF agents for rheumatoid arthritis and showed improvement following interruption of that treatment. Here, we discuss the relationship between anti-TNF therapy and the occurrence of autoimmune bullous disease. &lt;i&gt;Conclusion:&lt;\/i&gt; Anti-TNF agents should be considered as a potential cause of drug-induced autoimmune bullous skin disease.<\/jats:p>","DOI":"10.1159\/000318008","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T08:34:29Z","timestamp":1282206869000},"page":"201-205","source":"Crossref","is-referenced-by-count":64,"title":["Autoimmune Bullous Skin Diseases Occurring under Anti-Tumor Necrosis Factor Therapy: Two Case Reports"],"prefix":"10.1159","volume":"221","author":[{"given":"L.","family":"Boussemart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jacobelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Batteux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Goulvestre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Grange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Carlotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Morini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Gorin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Ziza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Avril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dupin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2009.04737.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0738-081X%2893%2990157-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semarthrit.2005.01.003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2165%2F00003495-200565050-00006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.berh.2008.09.008"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1027358528252"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2008.02.035"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa011592"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fjid.2008.412"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.8.1033"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1998.02169.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000247795"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000246749"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.05919.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.1.129"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clim.2006.03.014"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.11.022"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.59.4.263"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080%2F09546630802441234"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.25.022106.141557"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2009.08.046"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4049%2Fjimmunol.0900519"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/318008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/318008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:32:04Z","timestamp":1745436724000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000318008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":22,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,10,1]]},"published-print":{"date-parts":[[2010,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000318008","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}