{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:59:07Z","timestamp":1791219547668,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>Objectives: The effect of angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin II receptor blockers (ARBs) on the long-term outcome after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (PAF) is unknown. Methods: This matched-pair study included 102 patients with PAF treated with ACE-I or ARBs (group 1) and 102 control subjects (group 2) after standardized PVI. Tele-ECG recorders were used to detect the end point of the first PAF recurrence after a 3-month blanking period. Results: Median follow-up was 2.1 years (range 0.3\u20136.3). In group 1, 51 (50%) patients suffered recurrences, with a mean time to recurrence of 3.2 years (95% CI 2.6\u20133.8). In group 2, 67 (65.7%) patients presented PAF after a mean period of 2.2 years (95% CI 1.7\u20132.8; p = 0.009). A second ablation was performed in 31 (50%) patients from the treatment group and in 48 (66.7%) patients from the control group (p = 0.02). Multivariate Cox analysis showed treatment with ACE-I and ARBs to be the only significant predictor of a reduced recurrence rate (HR 0.49, 95% CI 0.32\u20130.75). Conclusion: ACE-I and ARBs were effective for the preservation of sinus rhythm after PAF ablation, and they reduced the reablation rate.<\/jats:p>","DOI":"10.1159\/000318016","type":"journal-article","created":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T02:43:56Z","timestamp":1285728236000},"page":"14-20","source":"Crossref","is-referenced-by-count":14,"title":["Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers on the Long-Term Outcome after Pulmonary Vein Isolation for Paroxysmal Atrial Fibrillation"],"prefix":"10.1159","volume":"117","author":[{"given":"Hanno U.","family":"Klemm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Heitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Ruprecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meinertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199809033391003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2003.12.054"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000144459.37455.EE"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2004.03.036"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc4601.099402"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000124487.36586.26"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2004.03.056"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2004.10.068"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2900611-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000022665.18619.83"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ehj.2003.08.014"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000091081.19465.F1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000151289.73085.36"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1540-8167.2002.01067.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1540-8167.2004.04125.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-8167.2005.00288.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2006.01.007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.2003.023069"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.1H583"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2006.09.006"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-8167.2007.00887.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2803%2900464-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2901939-3"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehl093"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1540-8167.2004.03371.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2005.11.033"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-199715090-00003"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/crd\/article-pdf\/117\/1\/14\/3892328\/000318016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/crd\/article-pdf\/117\/1\/14\/3892328\/000318016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T15:32:07Z","timestamp":1745422327000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000318016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,10,1]]},"published-print":{"date-parts":[[2010,10,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000318016","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}