{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:32:28Z","timestamp":1761975148630,"version":"3.40.4"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>We describe the 10-year outcome of the first-in-human series of 12 patients with hypertrophic cardiomyopathy treated with alcohol septal ablation. There was no 30-day mortality. Survival free of death, internal cardiac defibrillator discharge for treatment of ventricular fibrillation or tachycardia, severe New York Heart Association (NYHA) class III\/IV and\/or Canadian Cardiovascular Society class III\/IV symptoms and the need for surgical myectomy in this cohort was 91% at 1 year and 73% at 10 years. The reduction in outflow tract gradient was maintained over the 10 years, from a mean preoperative gradient of 70 mm Hg to a median of 3 mm Hg at 126 months of follow-up (p &lt; 0.01). Two patients (16%) underwent a further ablation procedure. Two patients (16%) suffered sudden cardiac death, 91 and 102 months after the procedure. Long-term symptom benefit was experienced by all patients, with a reduction in mean NYHA class from 2.7 \u00b1 0.6 before the procedure to 1 after the procedure at the last follow-up (p &lt; 0.01). This historic small cohort study demonstrates that septal ablation can provide long-term haemodynamic and symptomatic benefit.<\/jats:p>","DOI":"10.1159\/000318307","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T09:17:51Z","timestamp":1278667071000},"page":"168-173","source":"Crossref","is-referenced-by-count":15,"title":["Long-Term Follow-Up of the First Patients to Undergo Transcatheter Alcohol Septal Ablation"],"prefix":"10.1159","volume":"116","author":[{"given":"J.C.","family":"Lyne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kilpatrick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.J.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Sigwart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.M.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2895%2991267-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2897%2900508-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fheart.83.3.326"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2005.02.090"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-8183.2006.00153.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00392-007-0579-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901656-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2901003-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1540-8159.2005.09327.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901614-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jtcvs.2004.08.047"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1053%2Feuhj.2002.3285"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.euje.2004.01.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fclc.4960280305"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Feuhj.1999.1520"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2004.04.063"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.107.738740"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000165084.28065.01"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0735-1097%2889%2990343-4"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/318307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/318307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:34:46Z","timestamp":1745436886000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000318307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,8,1]]},"published-print":{"date-parts":[[2010,8,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000318307","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2010]]}}}