{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:01:09Z","timestamp":1793239269046,"version":"4.5.0"},"reference-count":106,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Vitamin D has been shown to have multiple biological targets mediated by the vitamin D receptor present in many cells. Specific actions on the central nervous system (CNS) have been described. The objective of this review was to describe the relationship between vitamin D and the nervous system throughout the different stages of life. &lt;i&gt;Methods:&lt;\/i&gt; A bibliographical search was performed in the MedLine and Cochrane library databases. The keywords used were: \u2018vitamin D\u2019 and \u2018nervous system\u2019 and\/or \u2018central nervous system\u2019 and\/or \u2018nervous system diseases\u2019 and\/or \u2018psychological tests\u2019 and\/or \u2018neuropsychological tests\u2019 and\/or \u2018mental disorders\u2019. The search period ranged from 01\/01\/1988 to 31\/10\/2009. Two hundred and ninety-five abstracts were first identified after screening. A final selection of 127 articles was used for the purpose of this review. &lt;i&gt;Results:&lt;\/i&gt; The studies published over the past 20 years provide an increasing number of arguments in favor of a life-long role of vitamin D on the nervous system as a whole, and in particular on the CNS. During cerebral development, vitamin D may act like a neurosteroid hormone in the areas of neurotransmission, neuroprotection, and neuroimmunomodulation. Moreover, vitamin D deficiency has been associated with neurological and psychiatric disorders. In older adults, hypovitaminosis D has been associated with neuromuscular disorders, dementia, and Parkinson\u2019s disease. Thus, vitamin D supplementation might have a protective effect against these neurological disorders. &lt;i&gt;Conclusions:&lt;\/i&gt; Vitamin D has been associated with many neurological functions and its deficiency with dysfunction. Low serum 25-hydroxyvitamin D concentrations can potentially be reversed. This simple and low-cost correction might contribute to the primo-secondary prevention of various neuropsychiatric disorders.<\/jats:p>","DOI":"10.1159\/000318570","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T07:04:42Z","timestamp":1279091082000},"page":"139-150","source":"Crossref","is-referenced-by-count":187,"title":["Vitamin D and Ageing: Neurological Issues"],"prefix":"10.1159","volume":"62","author":[{"given":"C\u00e9dric","family":"Annweiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Schott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Berrut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Chauvir\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Le Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Inzitari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Beauchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2FMCO.0b013e328010ca18"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1079%2FBJN2003837"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0891-0618%2899%2900002-2"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jchemneu.2004.08.006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2898%2900565-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0920-9964%2899%2900052-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2803%2900040-X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jsbmb.2006.12.096"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fpmic.200600392"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2801%2900049-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS1043-2760%2801%2900547-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0166-2236%2800%2901949-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.2.888"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2803%2900303-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-199412300-00032"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2899%2900255-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001250051443"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.86.10.3887"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2801%2900009-0"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F01.wnr.0000215770.79281.e4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-9861%2802%2900580-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainresbull.2005.06.022"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2004.07.008"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1080%2F01677060590949683"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neures.2005.12.008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.brainresbull.2005.10.014"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2004.03.023"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbr.2005.02.015"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.psyneuen.2006.12.006"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-005-0027-5"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pnpbp.2003.10.002"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2005.01.018"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016%2FS0074-7742%2804%2959014-1"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.physbeh.2004.03.004"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1007%2Fs007020070063"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1017%2FS003329170800319X"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.schres.2003.08.005"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mehy.2007.04.001"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016%2F0960-0760%2891%2990074-F"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1097%2F01.JGP.0000240986.74642.7c"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10067-006-0348-5"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpsyc.65.5.508"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02247486"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-1781%2893%2990031-B"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.seizure.2007.11.020"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1177%2F000992280504400512"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.1D467"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.2.5913.258"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2884%2991153-3"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2007.07.002"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.93.15.7861"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.65.6.809"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2007.11.014"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.296.23.2832"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.2174%2F092986708783503159"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1159%2F000166602"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2800%2900336-1"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1177%2F1352458509102459"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2008.12.011"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.2006.105320"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-006-0395-5"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000101723.79681.38"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1002%2Fjnr.490370212"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4547%2819980415%2952%3A2%3C210%3A%3AAID-JNR9%3E3.0.CO%3B2-D"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1006437003352"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-04-1968"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01420072"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11060-007-9418-z"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.1975.tb01358.x"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.2002.1c031.x"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdiacomp.2005.05.011"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.274.21.1683"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2009.02408.x"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1002%2Fbiof.4"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12603-009-0248-x"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.293.18.2257"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.2165%2F00002512-200724120-00005"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1093%2Fqjmed%2Fhcm005"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-008-0738-4"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1159%2F000103257"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-005-1860-1"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exger.2006.05.001"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2009.02755.x"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1016%2FS8756-3282%2898%2900134-3"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.abb.2006.12.018"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1159%2F000134382"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1177%2F0891988708327888"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.0b013e3181beecd3"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1159%2F000108918"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1093%2Fgerona%2Fglp032"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1601-5215.2002.51007.x"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1210%2Fendo-118-4-1433"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016%2F0169-328X%2892%2990032-7"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1620%2Ftjem.212.275"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2801%2902130-9"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.b.10026"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ceca.2006.04.001"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1042%2FBST0330573"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00198-008-0619-x"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00592-003-0062-6"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.65.10.1348"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.3346%2Fjkms.2005.20.3.495"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2801%2902450-7"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11064-006-9048-4"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1002%2Fmds.870120424"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1016%2F0021-9681%2879%2990012-2"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/318570","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/318570","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:35:38Z","timestamp":1745436938000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000318570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":106,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000318570","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}