{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:09:23Z","timestamp":1791144563911,"version":"4.1.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The aim of this work was to examine a possible association between a clinically relevant panic disorder and plasma total homocysteine concentration. &lt;i&gt;Methods:&lt;\/i&gt; 23 patients with panic disorder with or without agoraphobia confirmed by a standardized clinical interview (Structural Clinical Interview for DSM-IV-German version) and 23 healthy controls matched for gender and age completed questionnaires (SCL-K9, STAI, ADS, STAXI) and had blood drawn after a 15 min rest. Plasma total homocysteine concentrations were measured by competitive enzyme immunoassay. Interfering variables such as age, gender, smoking status, comorbid depression and medication were controlled for. &lt;i&gt;Results:&lt;\/i&gt; Patients with panic disorder had higher plasma homocysteine concentrations in comparison to the control group (mean value 11.00 vs. 9.14 \u00b5mol\/l, p = 0.04 with age, gender, smoking status, comorbid depression and antidepressant medication being controlled for). Furthermore, homocysteine plasma concentration was positively correlated with Global Severity of Symptoms (SCL-K9, r&lt;sub&gt;Pearson&lt;\/sub&gt; = 0.41, p &lt; 0.01). &lt;i&gt;Conclusion:&lt;\/i&gt; The findings of this study suggest a link between elevated plasma homocysteine levels and panic disorder. This raises a new hypothesis of another pathway to an increased risk of cardiovascular events in anxious individuals.<\/jats:p>","DOI":"10.1159\/000318573","type":"journal-article","created":{"date-parts":[[2010,7,14]],"date-time":"2010-07-14T07:04:42Z","timestamp":1279091082000},"page":"164-170","source":"Crossref","is-referenced-by-count":9,"title":["Relative Hyperhomocysteinemia in Patients with Panic Disorder: A Case-Control 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