{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:49:20Z","timestamp":1777441760847,"version":"3.51.4"},"reference-count":42,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T00:00:00Z","timestamp":1286496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T00:00:00Z","timestamp":1286496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Background\/Aims:<\/i> Vascular smooth muscle in Marfan syndrome, a connective tissue disorder caused by mutations in <i>FBN1<\/i> encoding fibrillin-1, is associated with decreased tonic contraction. As Ca<sup>2+<\/sup> waves are tightly associated with vasoconstriction, we hypothesized decreased tonic contraction in Marfan syndrome is due to aberrant Ca<sup>2+<\/sup> wave signaling. <i>Methods:<\/i> Isometric force and intracellular Ca<sup>2+<\/sup> were measured from second-order mesenteric arteries from mice heterozygous for the <i>Fbn1<\/i> allele encoding a cysteine substitution (<i>Fbn1<\/i><sup>C1039G\/+<\/sup>). <i>Results:<\/i> Phenylephrine concentration-dependently induced tonic contraction associated with sustained repetitive oscillations in intracellular [Ca<sup>2+<\/sup>] in both control and Marfan vessels, although Marfan vessels displayed significantly decreased Ca<sup>2+<\/sup> wave frequency and decreased number of cells exhibiting waves. Inhibition of sarcoplasmic reticulum Ca<sup>2+<\/sup> re-uptake by cyclopiazonic acid abolished Ca<sup>2+<\/sup> waves, dramatically decreasing tonic contraction. Nifedipine significantly reduced Ca<sup>2+<\/sup> wave frequency and tonic contraction, while the nifedipine-insensitive component was abolished by SKF-96365. Ca<sup>2+<\/sup> waves and tonic contraction were abolished by 2-aminoethoxydiphenylborate, but were unaffected by ryanodine or tetracaine. <i>Conclusion:<\/i> Phenylephrine-induced Ca<sup>2+<\/sup> waves underlie tonic contraction in resistance-sized mesenteric arteries and appear to be produced by repetitive cycles of regenerative Ca<sup>2+<\/sup> release from the sarcoplasmic reticulum. Decreased frequency of Ca<sup>2+<\/sup> waves in Marfan syndrome appears to be responsible for reduced tonic contraction.<\/jats:p>","DOI":"10.1159\/000318804","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T07:47:03Z","timestamp":1286524023000},"page":"150-162","source":"Crossref","is-referenced-by-count":8,"title":["Marfan Syndrome Decreases Ca<sup>2+<\/sup> Wave Frequency and Vasoconstriction in Murine Mesenteric Resistance Arteries without Changing Underlying Mechanisms"],"prefix":"10.1159","volume":"48","author":[{"given":"H.T.","family":"Syyong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.W.Y.","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"van 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