{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T09:11:06Z","timestamp":1768036266320,"version":"3.49.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recent genome-wide association studies have identified several genetic variants as susceptibility loci for serum uric acid (UA) levels. We also identified a common nonsense mutation, W258X, responsible for renal hypouricemia. Here, we investigated clinical implications of these genetic variants by cross-sectional and longitudinal genetic epidemiological analysis. &lt;i&gt;Methods:&lt;\/i&gt; The study enrolled 5,165 Japanese subjects aged 64 \u00b1 12 years from the general population. Clinical parameters were obtained from the personal health records, evaluated at medical checkups. &lt;i&gt;Results:&lt;\/i&gt; Serum UA levels were significantly different between the SLC22A12 rs11231825 (CC\/CT\/TT: 4.5 \u00b1 1.6, 5.0 \u00b1 1.4, 5.3 \u00b1 1.4 mg\/dl; p = 7.6 \u00d7 10&lt;sup&gt;\u201320&lt;\/sup&gt;), SLC2A9 rs1014290 (TT\/TG\/GG: 4.9 \u00b1 1.4, 5.1 \u00b1 1.4, 5.3 \u00b1 1.4 mg\/dl; p = 3.1 \u00d7 10&lt;sup&gt;\u201311&lt;\/sup&gt;) and ABCG2 rs2231142 (TT\/TG\/GG: 5.3 \u00b1 1.5, 5.2 \u00b1 1.4, 5.1 \u00b1 1.4 mg\/dl; p = 2.0 \u00d7 10&lt;sup&gt;\u20135&lt;\/sup&gt;) genotypes. During 9.4 years of follow-up, 87 new cases of hyperuricemia were diagnosed. Multiple logistic regression analysis identified the accumulation of risk alleles as a significant determinant of future development of hyperuricemia (OR = 7.94; 95% CI: 1.97\u201353.6). In contrast, subjects with nonsense mutation predominantly showed lower UA levels (XX\/XW\/WW: 1.3 \u00b1 1.7, 3.6 \u00b1 1.0, 5.2 \u00b1 1.4 mg\/dl; p = 9.3 \u00d7 10&lt;sup&gt;\u201382&lt;\/sup&gt;). However, these subjects showed significantly reduced renal function (\u03b2 = \u20130.111; p &lt; 0.001) independently of possible covariates. &lt;i&gt;Conclusion:&lt;\/i&gt; Accumulation of risk genotypes was an independent risk factor for future development of hyperuricemia. Genetically developed hypouricemia was an independent risk factor for decreased renal function.<\/jats:p>","DOI":"10.1159\/000318943","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T08:55:21Z","timestamp":1282121721000},"page":"279-286","source":"Crossref","is-referenced-by-count":33,"title":["Association of Four Genetic Loci with Uric Acid Levels and Reduced Renal Function: The J-SHIPP Suita Study"],"prefix":"10.1159","volume":"32","author":[{"given":"Yasuharu","family":"Tabara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Kohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuichi","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Hiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Morisaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kokubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonori","family":"Okamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitonobu","family":"Tomoike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoharu","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Miki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.106"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fng.107"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pgen.1000504"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2808%2961343-4"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.21499"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.lfs.2006.07.030"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cca.2008.09.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.00839.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-200X.2007.02337.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2337%2Fdb07-1785"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fijo.2009.161"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Faje%2Fkwg260"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra0800885"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000065637.10517.A0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000221716.55088.d4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161%2FATVBAHA.107.160184"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1021216713504"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1399-0004.2008.01021.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01892900"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2FMAJ.0b013e318164717f"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000105320.04395.D0"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1038%2Fajh.2008.245"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00467-005-1863-3"}],"container-title":["American 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