{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:17:47Z","timestamp":1767676667021,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Experimental data suggest that high-grade vascular stenosis may induce chronic cerebral tissue damage. &lt;i&gt;Methods:&lt;\/i&gt; We tested this hypothesis in 97 patients with a \u226770% unilateral internal carotid artery (ICA) stenosis (mean age: 69.1 \u00b1 10.2 years), comparing intraindividual side-to-side differences in hemispheric brain and white matter hyperintensity (WMH) volumes. Patients with a supratentorial infarct exceeding 1.5 cm in diameter were excluded. &lt;i&gt;Results:&lt;\/i&gt; Overall, the median WMH volume was greater in the hemisphere ipsilateral to the stenotic ICA (1.13 \u00b1 2.65 vs. 0.77 \u00b1 2.26 cm&lt;sup&gt;3&lt;\/sup&gt;; p = 0.005), but there were no differences in hemispheric brain volumes between the stenotic and nonstenotic sides. In the subgroup of patients with moderate and severe WMH (n = 41), the hemispheric volume ipsilateral to the stenotic ICA was significantly smaller (543.46 \u00b1 22.17 vs. 548.66 \u00b1 26.7 cm&lt;sup&gt;3&lt;\/sup&gt;; p = 0.03). Multivariate linear regression analysis revealed an independent effect of WMH grade on interhemispheric volume differences relative to the side of stenosis. &lt;i&gt;Conclusions:&lt;\/i&gt; Chronic tissue damage may occur in a subset of individuals with \u226770% ICA stenosis, globally exhibiting more extensive WMH.<\/jats:p>","DOI":"10.1159\/000319025","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T07:00:47Z","timestamp":1287126047000},"page":"540-546","source":"Crossref","is-referenced-by-count":20,"title":["High-Grade Internal Carotid Artery Stenosis and Chronic Brain Damage: A Volumetric Magnetic Resonance Imaging Study"],"prefix":"10.1159","volume":"30","author":[{"given":"Christian","family":"Enzinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ropele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gattringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Langkammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Fazekas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.108.527580"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejvs.2008.11.006"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejvs.2009.01.026"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2916146-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.556068"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000095385"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2377-8-51"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.expneurol.2007.12.005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jcbfm.9600563"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jcbfm.9600526"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000226774"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1006%2Fnimg.2002.1040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuroimage.2004.07.051"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1067%2Fmva.1993.42888"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1212%2F01.WNL.0000161871.83614.BB"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3174%2Fajnr.A1169"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.b2477"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000049147"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000255970"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-1331.2006.01115.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2214%2FAJR.07.3566"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2481070300"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20630"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-009-5449-z"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:39:16Z","timestamp":1745437156000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000319025","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2010]]}}}