{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:19:53Z","timestamp":1787505593611,"version":"build-2736575974"},"reference-count":35,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In patients with carotid artery stenosis, ipsilateral hemodynamic compromise is associated with an increased risk of stroke. It is unclear which factors determine cerebral perfusion. We studied the effect of both the degree of the stenosis and the collateral circulation via the circle of Willis (CoW) on cerebral perfusion in patients with symptomatic carotid artery stenosis. &lt;i&gt;Methods:&lt;\/i&gt; In 88 patients with unilateral symptomatic carotid artery stenosis of \u226750%, CT perfusion was used to measure the relative cerebral blood volume (rCBV), the difference in mean transit time (\u0394MTT) and the relative cerebral blood flow (rCBF). CT angiography was used to measure the degree of carotid stenosis and to assess the configuration of the CoW. Differences in mean rCBF, rCBV and \u0394MTT between patients with a carotid stenosis of \u226469, 70\u201379, 80\u201389 and 90\u201399%, and between patients with a complete and those with an incomplete CoW were determined by analysis of covariance. &lt;i&gt;Results:&lt;\/i&gt; The ipsilateral rCBF showed a gradual decrease with increasing severity of carotid stenosis (1.09 \u00b1 0.06, 0.93 \u00b1 0.06, 0.90 \u00b1 0.04 and 0.83 \u00b1 0.04 ml\/100 g\/min, respectively; p = 0.005), and the \u0394MTT showed a gradual increase (\u20130.02 \u00b1 0.33, 0.16 \u00b1 0.34, 1.08 \u00b1 0.22 and 1.47 \u00b1 0.20 s, respectively; p &lt; 0.001). The rCBV was not related to the severity of stenosis. No relation was found between the configuration of the CoW and the cerebral perfusion parameters. &lt;i&gt;Conclusions:&lt;\/i&gt; Cerebral perfusion is inversely related to the degree of stenosis in patients with symptomatic carotid artery stenosis. A relation between the configuration of the CoW and cerebral perfusion was not detected, suggesting that other collateral pathways play an important role.<\/jats:p>","DOI":"10.1159\/000319070","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T03:09:54Z","timestamp":1280113794000},"page":"277-284","source":"Crossref","is-referenced-by-count":44,"title":["Interrelation between the Degree of Carotid Stenosis, Collateral Circulation and Cerebral Perfusion"],"prefix":"10.1159","volume":"30","author":[{"given":"L.M.","family":"Jongen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.B.","family":"van der Worp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Waaijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"van der Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.P.T.M.","family":"Mali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199811123392002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2897%2909292-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F124.3.457"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000013671.70986.39"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000075605.36068.D9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199406023302204"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1067%2Fmva.1990.21479"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2001.94.4.0559"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410440206"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.30.5.1025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2912228-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000078753"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003300000707"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fmrm.20023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2271012173"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1148%2Fradiol.2451061493"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-009-1508-1"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000098326"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.55.11.1475"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-006-0192-1"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.30.5.1025"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000086465.41263.06"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000063719"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jcbfm.9600526"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-004-0569-y"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2968650-9"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2003.98.4.0828"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3171%2Fjns.2001.95.2.0206"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000177839.03321.25"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016%2FS0720-048X%2899%2900009-1"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10136"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00330-006-0209-2"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000209238.61459.39"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410290302"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawf047"}],"container-title":["Cerebrovascular 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