{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:55:29Z","timestamp":1789624529438,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<i>Aims:<\/i> To evaluate the potential role of serum cystatin C as a marker of renal function in patients with ovarian cancer. <i>Methods:<\/i> Treatment of consecutive ovarian cancer patients who were eligible for chemotherapy with paclitaxel (135 mg\/m<sup>2<\/sup>\/24 h) and cisplatin (75 mg\/m<sup>2<\/sup>) every 3 weeks in 6 cycles. Glomerular filtration rate (GFR) markers, i.e. serum levels of creatinine and cystatin C, estimated by the Cockcroft-Gault and Modification of Diet in Renal Disease formulas, were recorded before each cycle and 3 weeks after the 6th course. <i>Results:<\/i> The median age of 34 patients was 54 years. In the initial stage of treatment, we did not observe any correlation between cystatin C and other GFR markers. We noted a significant association between cystatin C and tumor extent on spiral CT scans (diameter: >1 cm) performed at baseline (p = 0.004), and after the 1st (p = 0.03) and 2nd cycle (p = 0.026). We observed a correlation between cystatin C and CA-125 level before chemotherapy (R = 0.4; p = 0.02) and after the 1st cycle (R = 0.43; p = 0.04). <i>Conclusion:<\/i> The results of our study suggest that cystatin C is not a reliable marker of the GFR in ovarian cancer patients, probably due to its nature as a cysteine protease inhibitor.<\/jats:p>","DOI":"10.1159\/000319097","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T08:55:21Z","timestamp":1282121721000},"page":"360-367","source":"Crossref","is-referenced-by-count":31,"title":["Cystatin C as a Parameter of Glomerular Filtration Rate in Patients with Ovarian Cancer"],"prefix":"10.1159","volume":"33","author":[{"given":"Lubomir","family":"Bodnar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Benedykt","family":"Wcislo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Smoter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Gasowska-Bodnar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Stec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Synowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cezary","family":"Szczylik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1990.182"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra054415"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.11.018"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fnbt0796-826b"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fmodpathol.3880309"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs005950170126"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejca.2008.08.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cccn.2004.02.007"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000180580"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10157-008-0043-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000092485"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cccn.2004.02.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biopha.2007.07.001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.canlet.2006.07.004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.canlet.2005.04.001"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ygyno.2003.11.017"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186%2Fbcr1312"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319097","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:39:56Z","timestamp":1745437196000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2010,11,1]]},"published-print":{"date-parts":[[2010,11,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000319097","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}