{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:17:43Z","timestamp":1778822263542,"version":"3.51.4"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T00:00:00Z","timestamp":1284508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T00:00:00Z","timestamp":1284508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; To study the effect of in-utero alcohol exposure on the insulin-like growth factor axis (IGF) and leptin during infancy and childhood, considering that exposed children may exhibit pre- and postnatal growth retardation. &lt;i&gt;Methods:&lt;\/i&gt; We prospectively identified heavily drinking pregnant women who consumed on average 4 or more drinks of ethanol per day (\u226748 g\/day) and assessed growth in 69 of their offspring and an unexposed control group of 83 children, measuring serum IGF-I (radioimmunoassay), IGF-II (immunoradiometric assay, IRMA), insulin-like growth factor-binding protein 3 (IGFBP-3) (IRMA) and leptin (IRMA) at 1 month and 1, 2, 3, 4, and 5 years of age. &lt;i&gt;Results:&lt;\/i&gt; IGF-II levels increased with age in both groups, but the rate of increase was significantly higher in exposed children, and levels were significantly higher in ethanol-exposed children at 3, 4, and 5 years of age. In exposed children, IGF-I levels were higher at 3 and 4 years and leptin levels were significantly lower at 1 and 2 years. Exposed subjects showed a much lower correlation between IGF-I and growth parameters than unexposed subjects. &lt;i&gt;Conclusion:&lt;\/i&gt; Exposure to ethanol during pregnancy increases IGF-I and IGF-II and decreases leptin during early childhood. The increase in serum IGF-II concentrations in ethanol-exposed children suggests that this hormone should be explored as a potential marker for prenatal alcohol exposure.<\/jats:p>","DOI":"10.1159\/000319706","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T09:09:14Z","timestamp":1288602554000},"page":"166-173","source":"Crossref","is-referenced-by-count":34,"title":["Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis"],"prefix":"10.1159","volume":"75","author":[{"given":"Sof\u00eda","family":"Aros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germ\u00e1n","family":"I\u00f1iguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Avila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary R.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Troendle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cassorla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fajmg.c.30013"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.51.9.703"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1996.tb13952.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200201000-00014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.placenta.2007.10.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1530-0277.1995.tb00960.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1530-0277.1993.tb05229.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1530-0277.1998.tb03692.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F10826080500391779"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0844"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2006.02650.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-0792"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-020633"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa010107"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-1597"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.87.6.2720"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199610313351805"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-1254"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159%2F000091503"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053%2Fplac.1999.0498"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0143-4004%2803%2900080-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1530-0277.1994.tb00877.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.2005.02225.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-1454"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-1390"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2003.50073"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319706","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319706","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:44:06Z","timestamp":1745437446000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,15]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,3,1]]},"published-print":{"date-parts":[[2011,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000319706","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,15]]}}}