{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:47:46Z","timestamp":1783399666864,"version":"3.54.6"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,12,13]],"date-time":"2010-12-13T00:00:00Z","timestamp":1292198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objective:<\/i> The present study was undertaken to evaluate the antinociceptive effects of an ayurvedic polyherbal formulation in rats and mice employing the tail immersion test and acetic acid-induced writhing test, respectively. <i>Materials and Methods:<\/i> With the tail immersion method, rats received two different doses (270 and 405 mg\/kg BW, p.o.) of a formulation, pethidine (5.4 mg\/kg BW, p.o.) as a reference standard and the combination of the higher dose of the formulation with naloxone (2 mg\/kg, i.p.), an opioid receptor antagonist, and caffeine (16 mg\/kg, i.p.), used as an adenosine receptor antagonist. In the acetic acid-induced writhing test, mice received two different doses (390 and 585 mg\/kg, BW, p.o.) of formulation, diclofenac sodium (15 mg\/kg, BW, p.o.) as a reference standard and the combination of the higher dose of the polyherbal formulation with ondansetron (0.5 mg\/kg, i.p.), a serotonin receptor antagonist. <i>Results:<\/i> The polyherbal formulation (405 mg\/kg) exhibited a significant (p < 0.01) antinociceptive effect using the tail immersion method. In the acetic acid-induced writhing test, the formulation showed significant (p < 0.01) dose-dependent activity. The antinociceptive effect of the polyherbal formulation apparently involved an opiate-like mechanism, since its antinociceptive action was attenuated by naloxone pretreatment. In addition, antinociceptive activity was attenuated by caffeine and reversed by ondansetron pretreatment. <i>Conclusion:<\/i> Our data suggest that the polyherbal formulation possessed centrally and peripherally mediated antinociceptive properties. The activity could be mediated through opioid, adenosine, and serotonin receptors and via inhibition of cyclo-oxygenase- and\/or lipoxygenase-dependent pathways.<\/jats:p>","DOI":"10.1159\/000319763","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T11:55:59Z","timestamp":1292327759000},"page":"66-70","source":"Crossref","is-referenced-by-count":3,"title":["Involvement of Opioid, Adenosine and 5-HT<sub>3<\/sub> Receptors in Antinociceptive Effects of an Ayurvedic Polyherbal Formulation"],"prefix":"10.1159","volume":"20","author":[{"given":"S.B.","family":"Chandrasekar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"Divakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.T.","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divakar","family":"Goli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Harisha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bhanumathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sushma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.N.","family":"Shivaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2007.06.025"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2004.09.034"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phymed.2003.12.009"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cbi.2006.09.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fptr.2183"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jss.2008.07.006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1078%2F0944-7113-00050"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2009.05.022"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2005.01.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-8741%2897%2900064-0"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3940%2892%2990927-Y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2880%2990377-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2886%2990074-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0379-0738%2889%2990154-0"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:45:02Z","timestamp":1745437502000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,13]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000319763","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,13]]}}}