{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:43:36Z","timestamp":1789951416704,"version":"4.0.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Atrial enlargement occurs in patients with significant mitral regurgitation. However, the time frame of the development of atrial enlargement induced by mitral regurgitation remains unknown. &lt;i&gt;Methods:&lt;\/i&gt; Fourteen Lanyu miniature pigs (age = 6.6 \u00b1 0.9 months) were studied. Mitral regurgitation was created by placing a predefined hole on the middle scallop of the posterior mitral leaflet under cardiopulmonary bypass. The parasternal long-axis atrial dimension was measured by transthoracic echocardiographic examinations. &lt;i&gt;Results:&lt;\/i&gt; All animals exhibited grade 3 mitral regurgitation immediately after surgery. Seven pigs expired within 2 weeks after the operation [technical complications (n = 1), acute cardiac tamponade (n = 1), and acute and subacute heart failure (n = 5)]. Seven pigs remained alive at a mean follow-up of 7.7 \u00b1 2.1 months. The left atrial diameter indices of the 7 pigs increased significantly at 1 month (33.1 \u00b1 8.6 mm, p = 0.018) and 3 months (41.3 \u00b1 12.6 mm, p = 0.018) after surgery compared with baseline values (22.8 \u00b1 5.2 mm), and the left atrial diameter index increased significantly at 3 months compared to 1 month (p = 0.018). &lt;i&gt;Conclusions:&lt;\/i&gt; Left atrial enlargement develops rapidly and progresses after the creation of significant pure mitral regurgitation.<\/jats:p>","DOI":"10.1159\/000319865","type":"journal-article","created":{"date-parts":[[2010,9,20]],"date-time":"2010-09-20T07:41:17Z","timestamp":1284968477000},"page":"98-104","source":"Crossref","is-referenced-by-count":5,"title":["Left Atrial Enlargement Induced by Pure Mitral Regurgitation: Time Frame in a New Swine Model"],"prefix":"10.1159","volume":"45","author":[{"given":"J.-P.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.-H.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-L.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.-H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-C.","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.-H.","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.-C.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,9,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardfail.2003.12.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2802%2903301-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.carpath.2007.07.008"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0894-7317%2803%2900335-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa041451"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2802%2901922-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2008.07.015"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2008.07.021"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jtcvs.2007.12.087"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.107.757526"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:45:44Z","timestamp":1745437544000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2010,10,1]]},"published-print":{"date-parts":[[2010,10,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000319865","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}