{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:22:58Z","timestamp":1761862978392,"version":"3.40.4"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T00:00:00Z","timestamp":1291939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T00:00:00Z","timestamp":1291939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background:<\/i> Cinacalcet reduces intact parathyroid hormone (iPTH), Ca and P serum levels in patients with secondary hyperparathyroidism (SHPT). <i>Methods:<\/i> This Spanish, multicenter, observational, retrospective study collected data from SHPT dialysis patients 12 weeks before and up to 72 weeks after starting cinacalcet in clinical practice. <i>Results:<\/i> Data from 428 patients with uncontrolled SHPT despite receiving standard of care (29% with baseline iPTH 501\u2013800 pg\/ml; 51% with >800 pg\/ml) were collected. Percentages of patients within National Kidney Foundation Kidney Disease Outcomes Quality Initiative targets at baseline and 72 weeks were: iPTH, 0 versus 32.5% (p < 0.05); Ca, 40.1 versus 50% (p < 0.05); P, 47.7 versus 53.8% (p = 0.162). Vitamin D sterol use decreased from 53.3% at baseline to 36.7% at 72 weeks (p < 0.05). The mean \u00b1 SD cinacalcet dose at 72 weeks was 44.0 \u00b1 25.8, 51.7 \u00b1 31.3 and 57.1 \u00b1 37.0 mg for patients with baseline iPTH 301\u2013500, 501\u2013800 or >800 pg\/ml, respectively. The main adverse reactions were nausea (5.4%), dyspepsia (5.1%) and vomiting (3.7%). <i>Conclusions:<\/i> The introduction of cinacalcet improved the routine clinical management of SHPT in a large cohort of Spanish dialysis patients. Cinacalcet is effective and well tolerated regardless of disease severity, and maintains its efficacy over 72 weeks.<\/jats:p>","DOI":"10.1159\/000319882","type":"journal-article","created":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T13:22:31Z","timestamp":1292332951000},"page":"c109-c121","source":"Crossref","is-referenced-by-count":13,"title":["Cinacalcet Treatment for Secondary Hyperparathyroidism in Dialysis Patients: An Observational Study in Routine Clinical Practice"],"prefix":"10.1159","volume":"118","author":[{"given":"Jordi","family":"Bover","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Ariza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Tornero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep Vicens","family":"Torregrosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Renal Osteodystrophy Group of the Spanish Society of Nephrology and all the investigators from the REHISET study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1081%2FJDI-120022551"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.07304.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2800%2970064-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.95.7.4040"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1385%2FENDO%3A10%3A2%3A97"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.642"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa031633"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004060512"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfp144"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.05241008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.29254"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.67139.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.03591006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2165%2F00044011-200828100-00004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn026"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000045"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.06510909"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00434.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl006"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi213"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00596.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.04381206"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319882","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:45:49Z","timestamp":1745437549000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319882"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,10]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,5,1]]},"published-print":{"date-parts":[[2011,5,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000319882","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"type":"electronic","value":"1660-2110"}],"subject":[],"published":{"date-parts":[[2010,12,10]]}}}