{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:24:07Z","timestamp":1788564247093,"version":"build-2803163510"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T00:00:00Z","timestamp":1288224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T00:00:00Z","timestamp":1288224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Chagas disease is endemic in South and Central America, where 18 million individuals are infected by &lt;i&gt;Trypanosoma cruzi&lt;\/i&gt;, causing congestive heart failure (CHF) and cardioembolic stroke. Transcranial Doppler (TCD) is able to detect real-time microembolic signals (MES) to the brain vessels and may represent a surrogate marker of stroke risk. We aimed to determine predictors of MES in a population of patients with CHF. &lt;i&gt;Methods:&lt;\/i&gt; Consecutive CHF patients from a university-based cardiomyopathy clinic underwent TCD recording of the middle cerebral artery for 60 min by a single investigator who was blinded to all clinical data including cardiomyopathy etiology. Predictors of MES were sought by multivariable logistic regression analysis. &lt;i&gt;Results:&lt;\/i&gt; From April 2004 to February 2009, 144 patients were studied, including 62 (44.6%) patients with Chagas disease. MES were detected in 9 (6.2%) patients and were more frequent in patients with Chagas disease than in patients with other causes of CHF (12.9 vs. 1.2%, p = 0.005). In multivariate analysis corrected for age and left-ventricular ejection fraction, predictors of MES were Chagas disease (odds ratio = 1.15, 95% confidence interval = 1.05\u20131.26, p = 0.004) and stroke history (odds ratio = 1.27, 95% confidence interval = 1.08\u20131.50, p = 0.005). &lt;i&gt;Conclusions:&lt;\/i&gt; Chagas disease and stroke history are risk factors for MES independent of cardiac disease severity. Other mechanisms besides structural cardiac disease may be operative, increasing embolic risk in Chagas disease.<\/jats:p>","DOI":"10.1159\/000319892","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T07:38:53Z","timestamp":1288251533000},"page":"19-23","source":"Crossref","is-referenced-by-count":13,"title":["Stroke History and Chagas Disease Are Independent Predictors of Silent Cerebral Microembolism in Patients with Congestive Heart Failure"],"prefix":"10.1159","volume":"31","author":[{"given":"Pedro A.P.","family":"Jesus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuri","family":"Neville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Cincur\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela F.","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo M.","family":"Vieira-de-Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda M.","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila C.","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davidson F.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter","family":"Ribeiro-dos-Santos, Jr.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.F.B.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamary","family":"Oliveira-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1590%2FS0066-782X2008001700004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000163104.92943.50"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000177866.13451.e4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.560854"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0404.2000.90342a.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000070544.15890.0E"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.72.3.338"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2FSTROKEAHA.109.563056"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM197112232852601"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa053241"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.63.6.784"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000015854"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1590%2FS0066-782X2003001200008"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199701233360403"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2897%2900019-3"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-009-5105-7"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:46:07Z","timestamp":1745437567000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,28]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,12,1]]},"published-print":{"date-parts":[[2010,12,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000319892","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,28]]}}}