{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:39:08Z","timestamp":1778870348996,"version":"3.51.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2011]]},"abstract":"<i>Objectives:<\/i> The aim of this prospective study was to assess the extent of dissemination of extended-spectrum \u03b2-lactamase (ESBL)-producing Enterobacteriaceae at the hospital level in the United Arab Emirates (UAE). <i>Materials and Methods:<\/i>A total of 662 <i>Escherichia coli <\/i>and <i>Klebsiella<\/i><i>pneumoniae<\/i> samples were collected from three UAE hospitals between January and December 2008. ESBL screening and confirmatory test for ESBL phenotype were conducted using the VITEK system. Molecular typing was performed using specific primers and then sequencing. <i>Results:<\/i> A total of 240 (36%) samples were identified as ESBL producers, including both <i>E. coli<\/i> (n = 150) and <i>K. pneumoniae<\/i> (n = 90). All of these isolates were resistant to cefazoline and cefotaxime, but remained susceptible to imipenem. Molecular analysis revealed that, of the 240 ESBL producers, 228 carried the ESBL <i>bla<\/i> genes. A majority of the strains 199 (87%) expressed the <i>CTX-M-15<\/i> gene. The <i>SHV-28<\/i> gene was detected in 29 (13%) of the strains. <i>Conclusion:<\/i> The present study highlighted the emergence and dissemination of CTX-M-15-producing <i>E. coli<\/i> and <i>K. pneumoniae<\/i> in the UAE. This is the first report of SHV-28-producing Enterobacteriaceae in the country.<\/jats:p>","DOI":"10.1159\/000319912","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T07:44:46Z","timestamp":1295595886000},"page":"177-180","source":"Crossref","is-referenced-by-count":18,"title":["Molecular Characterization and Epidemiology of Extended-Spectrum Beta-Lactamase-Producing <i>Escherichia coli<\/i> and <i>Klebsiella pneumoniae<\/i> Isolates in the United Arab Emirates"],"prefix":"10.1159","volume":"20","author":[{"given":"Mubarak Saif","family":"Alfaresi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abida A.","family":"Elkoush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajar M.","family":"Alshehhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeel Islam","family":"Abdulsalam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2011,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128%2FCMR.14.4.933-951.2001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.1.1-14.2004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01650727"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2006.01413.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000109587"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.01319-06"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.4.1204-1214.2004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.43.7.3309-3313.2005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.42.7.2902-2906.2004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkh397"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkf240"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.47.9.2864-2867.2003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkg103"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2003.07.004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.42.10.4769-4775.2004"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.1.362-364.2004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkg335"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.48.4.1249-1255.2004"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2Fdkg353"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3109%2F00313029309068906"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319912","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/319912","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:46:26Z","timestamp":1745437586000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000319912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,1,1]]},"published-print":{"date-parts":[[2011,1,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000319912","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}