{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:22:35Z","timestamp":1782300155350,"version":"3.54.5"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:00:00Z","timestamp":1285977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:00:00Z","timestamp":1285977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; In this study we hypothesised that proliferation, and the increased expression of G&lt;sub&gt;1&lt;\/sub&gt;-phase cyclins (D1, E) and phosphorylated retinoblastoma protein (p-Rb) is restricted to the early period of synchronized cyst growth in autosomal-recessive polycystic kidney disease (ARPKD). &lt;i&gt;Methods:&lt;\/i&gt; Lewis polycystic kidney disease &lt;i&gt;(lpk)&lt;\/i&gt; rats (model of ARPKD; postnatal weeks 1, 3, 6, 12 and 24; n = 6 each) as well as human juvenile cystic renal disease tissue (n = 2) were examined. &lt;i&gt;Results:&lt;\/i&gt; Between weeks 1 and 3, the percentage cyst area increased 6-fold in &lt;i&gt;lpk &lt;\/i&gt;rats, followed by a more progressive rise (1.5-fold increase) until week 24. The number of Ki-67-, cyclin D1- and p-Rb-positive cells increased in &lt;i&gt;lpk&lt;\/i&gt; rats and peaked at week 3, declining thereafter. By serial sections, cysts co-expressed Ki-67, cyclin D1 and p-Rb. The expression of cyclin E was variable, and peaked at week 24. In human tissue, small cysts had a higher expression of p-Rb. &lt;i&gt;Conclusion:&lt;\/i&gt; Proliferation and the increased nuclear expression of cyclin D1 and p-Rb coincide with the early phase of cyst growth in rats and humans, suggesting that there might be a therapeutic window in which cyclin-dependent kinase inhibitors are most effective in preventing kidney enlargement in ARPKD.<\/jats:p>","DOI":"10.1159\/000320149","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T06:55:59Z","timestamp":1286175359000},"page":"e93-e103","source":"Crossref","is-referenced-by-count":15,"title":["Early Cyst Growth Is Associated with the Increased Nuclear Expression of Cyclin D1\/Rb Protein in an Autosomal-Recessive Polycystic Kidney Disease Rat Model"],"prefix":"10.1159","volume":"117","author":[{"given":"Kristina G.","family":"Schwensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane 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Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:48:30Z","timestamp":1745437710000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,2]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000320149","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"value":"1660-2129","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,2]]}}}