{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:38:28Z","timestamp":1745469508731,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; We report on the serotype distribution and the antimicrobial susceptibility patterns (ASP) to 19 antibiotics of 195 &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; isolates (41 invasive) collected over the period 2001\u20132008 from adult patients. &lt;i&gt;Material and Methods:&lt;\/i&gt; Pneumococcal isolates were serotyped by the Quellung reaction, and ASP testing was performed using E-test. &lt;i&gt;Results:&lt;\/i&gt; Isolates with intermediate and high-level resistance to penicillin increased from 17 and 12.4% over the period 2001\u20132004 to 31.1 and 16.7% over the years 2005\u20132008, respectively (p = 0.03). Macrolide resistance increased from 27.6 to 38.9%, but this was not significant (p = 0.13), while resistance to trimethoprim-sulfamethoxazole did not change over time, with approximately one fourth of the isolates being resistant. Only one isolate was resistant to fluoroquinolones. Multi-resistance was observed among 42 (58.1%) penicillin non-susceptible strains. The isolates tested belonged to 20 different serotypes. Serotypes 19F and 19A were the most common among penicillin-resistant isolates. The currently licensed 23-valent pneumococcal polysaccharide vaccine covered 98.4% of all 186 typeable &lt;i&gt;S. pneumoniae&lt;\/i&gt; strains. &lt;i&gt;Conclusion:&lt;\/i&gt; Our study emphasizes the importance of continued serotyping and surveillance of antimicrobial susceptibility of all &lt;i&gt;S. pneumoniae&lt;\/i&gt; clinical isolates, especially invasive ones, in order to guide the clinician in the choice of appropriate empirical antibiotic therapy for serious pneumococcal infections.<\/jats:p>","DOI":"10.1159\/000320152","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T08:55:21Z","timestamp":1282121721000},"page":"325-332","source":"Crossref","is-referenced-by-count":8,"title":["Serotype Distribution and Antimicrobial Resistance of Adult &lt;i&gt;Streptococcus pneumoniae&lt;\/i&gt; Clinical Isolates over the Period 2001\u20132008 in Crete, Greece"],"prefix":"10.1159","volume":"56","author":[{"given":"S.","family":"Maraki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mantadakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Samonis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2105%2FAJPH.90.2.223"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.264.22.2910"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093%2Fjac%2F49.1.31"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2006.01395.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1843.2008.01422.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2877%2992892-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2009.02724.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2007.07.035"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0924-8579%2801%2900330-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-004-1447-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.45.6.1721-1729.2001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2007.03.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1086%2F591966"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1086%2F503805"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086%2F594125"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1086%2F315761"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1086%2F323339"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1086%2F425368"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10096-005-0032-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1469-0691.2006.01397.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijantimicag.2009.02.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1086%2F324525"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1086%2F516779"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199508243330803"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1086%2F423820"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1086%2F524660"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000214144"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000220828"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:48:31Z","timestamp":1745437711000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000320152","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2010]]}}}