{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:44:34Z","timestamp":1766983474319,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:00:00Z","timestamp":1285977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,10,2]],"date-time":"2010-10-02T00:00:00Z","timestamp":1285977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; SM22\u03b1, transgelin, is abundantly expressed in smooth muscle tissues and our previous work demonstrated that it is a novel marker of injured glomerular epithelial cells in rat antiglomerular basement membrane nephritis. In this study, we investigated SM22\u03b1 expression in models of glomerular and interstitial renal injury. &lt;i&gt;Methods:&lt;\/i&gt; The 5\/6 nephrectomy (Nx) model, ischemia-reperfusion (I\/R) model and puromycin aminonucleoside (PAN) nephrosis of rats were studied. Immunohistochemical analyses and immunoelectron microscopic studies of SM22\u03b1 expression were performed. &lt;i&gt;Results:&lt;\/i&gt; In the 5\/6 Nx model, SM22\u03b1 was first expressed in peritubular interstitial cells and was also expressed in injured glomerular epithelial cells at 8 weeks. In the I\/R model, SM22\u03b1 expression was induced in peritubular interstitial cells as early as 12 h after I\/R with expression sustained at 7 days. However, SM22\u03b1 was not detected in any glomerular cells or tubular epithelial cells. In PAN nephrosis, SM22\u03b1 was only expressed in glomerular epithelial cells after 1 week, but expression was transient. &lt;i&gt;Conclusion:&lt;\/i&gt; SM22\u03b1 was expressed in glomerular epithelial cells and interstitial cells in renal injury. SM22\u03b1 is differentially upregulated in various models of renal injury and merits further study.<\/jats:p>","DOI":"10.1159\/000320175","type":"journal-article","created":{"date-parts":[[2010,10,4]],"date-time":"2010-10-04T06:55:59Z","timestamp":1286175359000},"page":"e104-e113","source":"Crossref","is-referenced-by-count":4,"title":["Expression of SM22\u03b1 (Transgelin) in Glomerular and Interstitial Renal Injury"],"prefix":"10.1159","volume":"117","author":[{"given":"Shigeru","family":"Inomata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Sakatsume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumitake","family":"Gejyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiei","family":"Narita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biocel.2008.02.011"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-0436.1993.tb00027.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000126417.38728.F6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1006%2Fgeno.1998.5267"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0169%281997%2938%3A3%3C250%3A%3AAID-CM3%3E3.0.CO%3B2-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000103020"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000067651.34743.B0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.107.123638"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00500.2007"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1797.2005.00412.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2000.00097.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2353%2Fajpath.2006.060043"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00380.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F12.5.904"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.suppl_9.20"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00280.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.059003959.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2001.0590051911.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.07-083857"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000033611.79556.AE"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yjmcc.2003.09.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bbrc.2006.07.009"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00428-005-0134-9"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:48:38Z","timestamp":1745437718000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,2]]},"references-count":23,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2011,4,1]]},"published-print":{"date-parts":[[2011,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000320175","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"type":"electronic","value":"1660-2129"}],"subject":[],"published":{"date-parts":[[2010,10,2]]}}}