{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T01:26:43Z","timestamp":1781659603022,"version":"3.54.5"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2010]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; A mass &lt;i&gt;Entamoeba histolytica&lt;\/i&gt; infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. &lt;i&gt;Methods:&lt;\/i&gt; Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy in mentally disabled individuals infected with &lt;i&gt;E. histolytica&lt;\/i&gt; at an institution (the prevalence rate and positive serology rate were 38.2 and 67.1%, respectively). The therapeutic effect of the drugs was judged by microscopic stool examination and an &lt;i&gt;E. histolytica&lt;\/i&gt; antigen detection kit. &lt;i&gt;Results:&lt;\/i&gt; The mass infection was eliminated through the administration of metronidazole and subsequent use of diloxanide furoate. &lt;i&gt;Conclusions:&lt;\/i&gt; Combination therapy successfully cured and prevented transmission of the mass &lt;i&gt;E. histolytica&lt;\/i&gt; infection at the institution.<\/jats:p>","DOI":"10.1159\/000320187","type":"journal-article","created":{"date-parts":[[2010,8,18]],"date-time":"2010-08-18T08:55:21Z","timestamp":1282121721000},"page":"348-352","source":"Crossref","is-referenced-by-count":7,"title":["Difficulties in the Treatment of Intestinal Amoebiasis in Mentally Disabled Individuals at a Rehabilitation Institution for the Intellectually Impaired in Japan"],"prefix":"10.1159","volume":"56","author":[{"given":"Tsukasa","family":"Fujishima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichi","family":"Nishise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Ichihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,8,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.arcmed.2005.09.010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128%2FJCM.41.8.3748-3756.2003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200210243471722"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0035-9203%2868%2990170-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.00909-08"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000112416"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000226426"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:48:42Z","timestamp":1745437722000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000320187","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010]]}}}