{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:13:12Z","timestamp":1790691192228,"version":"4.1.0"},"reference-count":38,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T00:00:00Z","timestamp":1283212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T00:00:00Z","timestamp":1283212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background\/Aim:<\/i> Pulse pressure (PP) is a result of arterial stiffness seen in dialysis patients, but may be a consequence of fluid overload. We examined the role of \u03b2<sub>2<\/sub>-microglobulin (\u03b2<sub>2<\/sub>M) in PP in relation to metabolic alterations in patients on different hemodialysis (HD) modalities. <i>Methods:<\/i> We studied 76 hemodialyzed patients on regular HD (n = 34), predilution bagged hemodiafiltration (n = 19) and online predilution hemodiafiltration (n = 23). \u03b2<sub>2<\/sub>M levels were measured by radioimmunoassay, and the clearance of \u03b2<sub>2<\/sub>M was assessed by Kt\/V for \u03b2<sub>2<\/sub>M. Arterial stiffness was measured as carotid-femoral pulse wave velocity, and PP was derived. Insulin levels were measured using immunoradioassay, and insulin resistance was calculated using homeostasis model assessment insulin resistance (HOMA-IR). Serum bicarbonate levels were measured using a blood gas analyzer, and percent sodium removal was calculated. <i>Results:<\/i> \u03b2<sub>2<\/sub>M levels predict increased PP (p = 0.02) adjusting for age, HD modalities, HD duration, HOMA-IR and percent sodium removal. \u03b2<sub>2<\/sub>M was positively associated with HOMA-IR (r = 0.306, p = 0.007). Serum bicarbonate levels and carotid-femoral pulse wave velocity were inversely associated (r = \u20130.719, p = 0.001). <i>Conclusions:<\/i> \u03b2<sub>2<\/sub>M levels were positively associated with PP, which was influenced mainly by dialysis modality fluid and sodium balance and less by arterial stiffness. \u03b2<sub>2<\/sub>M levels were positively associated with insulin resistance. Uremic acidosis may contribute to arterial stiffness.<\/jats:p>","DOI":"10.1159\/000320193","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T14:38:27Z","timestamp":1283524707000},"page":"c237-c245","source":"Crossref","is-referenced-by-count":17,"title":["\u03b2<sub>2<\/sub>-Microglobulin, Pulse Pressure and Metabolic Alterations in Hemodialysis Patients"],"prefix":"10.1159","volume":"117","author":[{"given":"Vaia D.","family":"Raikou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Tentolouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Kyriaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Evaggelatou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Tzanatou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2010,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000249379.55535.21"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0894-0959.2004.17606.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000096373.13406.94"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2887%2990266-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005020132"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2800%2970041-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000238822"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004030203"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn521"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000070242"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fsnep.2001.21660"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.suppl_1.37"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh775"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfh315"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000170328"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000029849"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F14.5.1202"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000199432"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfp662"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000249379.55535.21"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.28.505"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.30.377"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.104.513085"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.106.683722"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ackd.2008.07.011"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.27.47"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5002164"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1159%2F000070205"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159%2F000169600"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1097%2FHJH.0b013e328331b81e"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.2001.20764"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1159%2F000188471"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199612193352507"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1097%2FMAJ.0b013e3181a4158c"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2007.02.032"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F15.7.1014"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10157-005-0385-4"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000141775.67189.98"}],"container-title":["Nephron 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