{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:23:24Z","timestamp":1776896604492,"version":"3.51.2"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T00:00:00Z","timestamp":1282608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2010,8,24]],"date-time":"2010-08-24T00:00:00Z","timestamp":1282608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2011]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Sensitization to weed pollen allergens at the molecular level is not fully understood. We studied IgE reactivity to the major mugwort allergen Art v 1 in relation to allergens from other weed pollen and cross-reactive components in mugwort-sensitized subjects. &lt;i&gt;Methods:&lt;\/i&gt; Art v 1 and Amb a 1 were affinity purified and coupled to experimental ImmunoCAP\u00ae tests. Samples from North Europe (n = 50), South Europe (n = 19) and North America (n = 41) were analyzed for IgE against mugwort pollen, weed allergen components, pan-allergens and cross-reactive carbohydrate determinants (CCDs). &lt;i&gt;Results:&lt;\/i&gt; The prevalence of IgE reactivity (&gt;0.35 kU&lt;sub&gt;A&lt;\/sub&gt;\/l) to Art v 1 was significantly higher in samples from North Europe than in those from North America. IgE to Amb a 1 was more common in North America than in North and South Europe, while IgE to Par j 2 was common in South Europe, less common in North America, and absent in North Europe. IgE to Art v 3 in mugwort-allergic patients was more common in North Europe than in South Europe and North America, while IgE to Sal k 1 was similar between the areas. Subjects with an Art v 1\/mugwort-specific IgE ratio &lt;0.5 had more often IgE to Amb a 1, profilin, polcalcin and CCDs than subjects with a ratio &gt;0.5. &lt;i&gt;Conclusions:&lt;\/i&gt; Mugwort-sensitized subjects have different IgE reactivity profiles to weed allergens, reflecting their exposure to various pollens. Subjects with a low ratio between the IgE levels to Art v 1 and mugwort have a diverse IgE reactivity profile, indicating a role for cross-reactive allergens in their mugwort sensitization.<\/jats:p>","DOI":"10.1159\/000320231","type":"journal-article","created":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T06:17:29Z","timestamp":1282717049000},"page":"164-172","source":"Crossref","is-referenced-by-count":34,"title":["Mugwort-Sensitized Individuals from North Europe, South Europe and North America Show Different IgE Reactivity Patterns"],"prefix":"10.1159","volume":"154","author":[{"given":"Robert","family":"Mov\u00e9rare","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raimo","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Holmquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2010,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2007.01393.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molimm.2008.10.012"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000096114"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2003.01631.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.02053.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2008.01780.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2007.02744.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000089188"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2898%2970384-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2006.02477.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1021%2Fbi00859a017"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.107927"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Felps.1150080203"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1021%2Fac950914h"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1021%2Fac035331j"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0003-9861%2881%2990351-9"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2002.01467.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000108134"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2008.01807.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2009.03351.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.1376"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-5793%2896%2901328-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.molimm.2009.03.021"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2002.13248.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000057742"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1586%2F14760584.2.1.85"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.1999.00653.x"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320231","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/320231","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T19:49:05Z","timestamp":1745437745000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000320231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,24]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2011,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000320231","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,24]]}}}